TNF-α blockade may lead to improvement of vascular function in psoriasis patients.

Autor: Wegner J; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Karbach S; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.; Center of Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.; German Center for Cardiovascular Research (DZHK, Greifswald, Germany., Drosos I; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., Schnorbus B; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., Muxel S; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., Schmidt F; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany., Wenzel P; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.; Center of Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.; German Center for Cardiovascular Research (DZHK, Greifswald, Germany., Waisman A; Institute of Molecular Medicine, University Medical Center Mainz, Mainzm, Germany., Münzel T; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.; Center of Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.; German Center for Cardiovascular Research (DZHK, Greifswald, Germany., Gori T; Center of Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany.; German Center for Cardiovascular Research (DZHK, Greifswald, Germany., von Stebut E; Department of Dermatology, University of Cologne, University Hospital Cologne and Faculty of Medicine Cologne, Cologne, Germany.
Jazyk: angličtina
Zdroj: Experimental dermatology [Exp Dermatol] 2022 Feb; Vol. 31 (2), pp. 237-241. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1111/exd.14452
Abstrakt: Psoriasis is one of the most common chronic inflammatory skin diseases and at the same time a risk factor for cardiovascular disease. Interleukin-17A (IL-17A)-mediated inflammation in psoriasis may lead to vascular dysfunction. This study aimed at investigating whether anti-inflammatory treatment by tumor necrosis factor (TNF)-α blockade alters vascular function in psoriasis patients. A total of 11 patients with psoriasis who underwent treatment with either adalimumab (n = 8) or etanercept (n = 3), 10 healthy control individuals and 14 patients with coronary artery disease (CAD) were included in this study. Treatment response was assessed using the Psoriasis Area and Severity Index (PASI) score. Endothelial reactivity and resting endothelium-dependent vascular tone were assessed by ultrasound measurement of flow-mediated dilation (FMD) and low-flow-mediated constriction (l-FMC), respectively. FMD was slightly impaired in psoriasis patients compared to healthy controls. Anti-TNF-α treatment did not significantly change FMD levels. Psoriasis patients showed a trend towards increased baseline vascular activity compared to healthy controls. Anti-TNF-α treatment significantly improved l-FMC in psoriasis patients. Noteworthy, both FMD and l-FMC in psoriasis patients were comparable to those in patients with CAD; however, an important influence of age differences between the groups or co-existent classical cardiovascular risk factors on FMD and l-FMC cannot be ruled out by our small study. The results suggest that anti-inflammatory treatment with TNF-α blockade improves vascular function in patients with psoriasis, mainly by altering baseline vascular tone. Further studies will be necessary to establish the potentially protective impact of anti-inflammatory therapy on vascular function in patients with chronic inflammatory diseases.
(© 2021 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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