Adenosine A 1 receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity.
Autor: | Jain S; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA., Barella LF; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA., Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA., Reitman ML; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA., Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. Electronic address: kennethj@niddk.nih.gov. |
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Jazyk: | angličtina |
Zdroj: | Biochemical pharmacology [Biochem Pharmacol] 2021 Oct; Vol. 192, pp. 114739. Date of Electronic Publication: 2021 Aug 19. |
DOI: | 10.1016/j.bcp.2021.114739 |
Abstrakt: | Hepatic insulin resistance (IR) and enhanced hepatic glucose production (HGP) are key features of type 2 diabetes (T2D), contributing to fasting hyperglycemia. Adenosine receptors (ARs) are G protein-coupled and expressed in hepatocytes. Here, we explored the role of hepatic G (Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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