Topological braiding and virtual particles on the cell membrane.

Autor:	Liu J; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139., Totz JF; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139., Miller PW; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010., Hastewell AD; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139., Chao YC; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138., Dunkel J; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139; dunkel@mit.edu fakhri@mit.edu., Fakhri N; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139; dunkel@mit.edu fakhri@mit.edu.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Aug 24; Vol. 118 (34).
DOI:	10.1073/pnas.2104191118
Abstrakt:	Braiding of topological structures in complex matter fields provides a robust framework for encoding and processing information, and it has been extensively studied in the context of topological quantum computation. In living systems, topological defects are crucial for the localization and organization of biochemical signaling waves, but their braiding dynamics remain unexplored. Here, we show that the spiral wave cores, which organize the Rho-GTP protein signaling dynamics and force generation on the membrane of starfish egg cells, undergo spontaneous braiding dynamics. Experimentally measured world line braiding exponents and topological entropy correlate with cellular activity and agree with predictions from a generic field theory. Our analysis further reveals the creation and annihilation of virtual quasi-particle excitations during defect scattering events, suggesting phenomenological parallels between quantum and living matter. Competing Interests: The authors declare no competing interest.
Databáze:	MEDLINE
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