Evaluation of Characteristics and Outcomes for Patients with Diabetic Ketoacidosis (DKA) With and Without COVID-19 in Elmhurst Queens During Similar Three-Month Periods in 2019 and 2020.

Autor: Patel U; Internal Medicine, Mount Sinai Elmhurst Hospital, New York, USA., Deluxe L; Endocrinology, Mount Sinai Elmhurst Hospital, New York, USA., Salama C; Internal Medicine, Mount Sinai Elmhurst Hospital, New York, USA., Jimenez AR; Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA., Whiting A; Internal Medicine, Mount Sinai Elmhurst Hospital, New York, USA., Lubin C; Internal Medicine, Mount Sinai Elmhurst Hospital, New York, USA., Tarlin N; Endocrinology, Icahn School of Medicine Mount Sinai / NYC Health + Hospitals/Elmhurst, New York City, USA.
Jazyk: angličtina
Zdroj: Cureus [Cureus] 2021 Jul 16; Vol. 13 (7), pp. e16427. Date of Electronic Publication: 2021 Jul 16 (Print Publication: 2021).
DOI: 10.7759/cureus.16427
Abstrakt: Aim There are reports of COVID-19 patients presenting with new onset diabetes, diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic syndrome (HHS). We compared the characteristics of patients with DKA with and without COVID-19 and their effect on mortality. Research design and methods A retrospective study at Elmhurst Hospital Center in Queens, New York was performed using ICD-10 codes to identify patients with DKA from March 1 to May 31 in 2019 and 2020. Results While comparing COVID-19 patients with DKA to the DKA patients without COVID-19 in both 2019 and 2020, hispanic patients, males, and type 2 diabetes predominated. COVID-19 patients were older (p=0.010), had more hypertension (p=0.002), and severe lactic acidosis (p=0.006). Mortality for DKA patients with COVID-19 was 57%, for DKA patients without COVID-19 it was 2.1% (p=0.0001), and for diabetic patients (no DKA) with COVID-19 it was 39% (p=0.035). Within the COVID-19 group, older age (mean age 65), (p=0.014), elevated CRP (p=0.012), low O 2 saturation (p=0.001), and beta blocker use (P=0.01) were associated with increased mortality. Conclusions COVID-19 patients are older, have a history of hypertension, more severe DKA and lactic acidosis than patients without COVID-19. There was no increase in DKA with HHS. DKA, but not diabetic parameters, hypertension, and older age predicted a poor outcome.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2021, Patel et al.)
Databáze: MEDLINE
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