Location, morphology and invasiveness of lateral spreading tumors in the colorectum differ between two large cohorts from an eastern and western country.

Autor:	Guarner-Argente C; Gastroenterology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Ikematsu H; Division of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Japan., Osera S; Gastroenterology Department, Saku Central Hospital Advanced Care Center, Japan., Fraile M; Gastroenterology Department, Hospital de San Pedro, Logroño, Spain., Ibañez B; Statistics, NavarraBiomed-Fundación Miguel Servet-IDISNA, Pamplona, Spain., Marra-López C; Gastroenterology Department, Complejo Hospitalario de Navarra, Pamplona, Spain., Jerusalén-Gargallo C; Gastroenterology Department, Complejo Hospitalario de Navarra, Pamplona, Spain., Alonso Aguirre PA; Gastroenterology Department, Complexo Hospitalario A Coruña, Spain., Martinez-Ares D; Gastroenterology Department, Complejo Hospitalario de Vigo Hospital Xeral, Spain., Soto S; Gastroenterology Department, Complexo Hospitalario de Ourense, Spain., Ramos Zabala F; Gastroenterology Department, HM Monteprincipe University Hospital, Madrid, Spain., Alvarez-Gonzalez MA; Endoscopy Unit, Hospital del Mar, Barcelona, Spain., Rodriguez Sánchez J; Endoscopy Department, Hospital General Universitario de Ciudad Real, Spain., Múgica F; Gastroenterology Department, Hospital Universitario de Donostia, Spain., Nogales Rincon O; Department of Gastroenterology and Hepatology, HGU Gregorio Marañon, Madrid, Spain., Herreros de Tejada A; Aparato Digestivo, Hospital Universitario Puerta del Hierro, Majadahonda, Spain., Redondo-Cerezo E; Gastroenterology Department, Virgen de las Nieves Hospital, Granada, Spain., Martínez-Cara J; Gastroenterology Department, Virgen de las Nieves Hospital, Granada, Spain., López-Rosés L; Endoscopy Unit, Hospital Lucus Augusti, Lugo, Spain., Rodriguez-Tellez M; Digestive Diseases, Virgen Macarena University Hospital, Sevilla, Spain., Garcia-Bosch O; Gastroenterology Department, Hospital Sant Joan Despi Moises Broggi, Barcelona, Spain., de la Peña J; Endoscopy Unit, H. Virtual Valdecilla, Santander, Spain., Pellisé M; Gastroenterology Department, Hospital Clínic de Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain., Rivero-Sanchez L; Gastroenterology Department, Hospital Clínic de Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain., Saperas E; Gastroenterology Department, Hospital General de Catalunya, Barcelona, Spain., Pérez-Roldán F; Gastroenterology Department, Complejo Hospitalario La Mancha Centro, Ciudad Real, Spain., Lopez Viedma B; Gastroenterology Department, Hospital General de Ciudad Real, Spain., González-Santiago JM; Gastroenterology Department, Complejo Asistencial Universitario de Salamanca, Spain., Álvarez Delgado A; Gastroenterology Department, Complejo Asistencial Universitario de Salamanca, Spain., Cobian C; Gastroenterology Department, Hospital Universitario de Donostia, Spain., Pardeiro R; Gastroenterology Department, Complexo Hospitalario A Coruña, Spain., Valdivielso Cortázar E; Gastroenterology Department, Complexo Hospitalario A Coruña, Spain., Colan-Hernandez J; Gastroenterology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Gordillo J; Gastroenterology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Kaneko K; Division of Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Japan., Albéniz E; Gastroenterology Department, Complejo Hospitalario de Navarra, Pamplona, Spain; Navarrabiomed, Universidad Pública de Navarra, IdiSNa, Pamplona, Spain. Electronic address: edualbeniz@hotmail.com.
Jazyk:	English; Spanish; Castilian
Zdroj:	Gastroenterologia y hepatologia [Gastroenterol Hepatol] 2022 Jun-Jul; Vol. 45 (6), pp. 440-449. Date of Electronic Publication: 2021 Aug 14.
DOI:	10.1016/j.gastrohep.2021.07.005
Abstrakt:	Background and Study Aims: Data from Japanese series show that surface morphology of laterally spreading tumors (LST) in the colon identifies lesions with different incidence and pattern of submucosal invasion. Such data from western countries are scarce. We compared clinical and histological features of LST in a western country and an eastern country, with special interest on mucosal invasiveness of LST, and investigated the effect of clinical factors on invasiveness in both countries. Patients and Methods: Patients with LST lesions ≥20mm were included from a multicenter prospective registry in Spain and from a retrospective registry from the National Cancer Center Hospital East, Japan. The primary outcome was the presence of submucosal invasion in LST. The secondary outcome was the presence of high-risk histology, defined as high-grade dysplasia or submucosal invasion. Results: We evaluated 1102 patients in Spain and 663 in Japan. Morphological and histological characteristics differed. The prevalence of submucosal invasion in Japan was six-fold the prevalence in Spain (Prevalence Ratio PR=5.66; 95%CI: 3.96, 8.08), and the prevalence of high-risk histology was 1.5 higher (PR=1.44; 95%CI: 1.31, 1.58). Compared to the granular homogeneous type and adjusted by clinical features, granular mixed, flat elevated, and pseudo-depressed types were associated with higher odds of submucosal invasion in Japan, whereas only the pseudo-depressed type showed higher risk in Spain. Regarding high-risk histology, both granular mixed and pseudo-depressed were associated with higher odds in Japan, compared with only the granular mixed type in Spain. Conclusion: This study reveals differences in location, morphology and invasiveness of LST in an eastern and a western cohort. (Copyright © 2021 Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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