Impact of Perioperative Complications on Living Kidney Donor Health-Related Quality of Life and Mental Health: Results From a Prospective Cohort Study.

Autor:	Garcia-Ochoa C; London Health Sciences Centre, ON, Canada., Feldman LS; Department of Surgery, McGill University Health Centre, Montreal, QC, Canada., Nguan C; The University of British Columbia, Vancouver, Canada., Monroy-Caudros M; Foothills Medical Center, University of Calgary, AB, Canada., Arnold JB; London Health Sciences Centre, ON, Canada., Barnieh L; London Health Sciences Centre, ON, Canada., Boudville N; Medical School, Department of Renal Medicine, Sir Charles Gairdner Hospital, The University of Western Australia, Perth, Australia., Cuerden MS; London Health Sciences Centre, ON, Canada., Dipchand C; Division of Nephrology, Dalhousie University, Halifax, NS, Canada., Gill JS; The University of British Columbia, Vancouver, Canada., Karpinski M; University of Manitoba, Winnipeg, Canada., Klarenbach S; Division of Nephrology, University of Alberta, Edmonton, Canada., Knoll G; Division of Nephrology, Department of Medicine, University of Ottawa, ON, Canada., Lok CE; University of Toronto, ON, Canada., Miller M; Division of Nephrology and Transplantation, St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, ON, Canada., Prasad GVR; St. Michael's Hospital, Toronto, ON, Canada., Sontrop JM; Department of Epidemiology & Biostatistics, Western University, London, ON, Canada., Storsley L; University of Manitoba, Winnipeg, Canada., Garg AX; Department of Epidemiology & Biostatistics, Western University, London, ON, Canada.; Department of Medicine, Western University, London, ON, Canada.; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Jazyk:	angličtina
Zdroj:	Canadian journal of kidney health and disease [Can J Kidney Health Dis] 2021 Aug 11; Vol. 8, pp. 20543581211037429. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).
DOI:	10.1177/20543581211037429
Abstrakt:	Background: Although living kidney donation is safe, some donors experience perioperative complications. Objective: This study explored how perioperative complications affected donor-reported health-related quality of life, depression, and anxiety. Design: This research was a conducted as a prospective cohort study. Setting: Twelve transplant centers across Canada. Patients: A total of 912 living kidney donors were included in this study. Measurements: Short Form 36 health survey, Beck Depression Inventory and Beck Anxiety Inventory. Methods: Living kidney donors were prospectively enrolled predonation between 2009 to 2014. Donor perioperative complications were graded using the Clavien-Dindo classification system. Mental and physical health-related quality of life was assessed with the 3 measurements; measurements were taken predonation and at 3- and 12-months postdonation. Results: Seventy-four donors (8%) experienced a perioperative complication; most were minor (n = 67 [91%]), and all minor complications resolved before hospital discharge. The presence (versus absence) of a perioperative complication was associated with lower mental health-related quality of life and higher depression symptoms 3-month postdonation; neither of these differences persisted at 12-month. Perioperative complications were not associated with any changes in physical health-related quality of life or anxiety 3-month postdonation. Limitations: Minor complications may have been missed and information on complications postdischarge were not collected. No minimal clinically significant change has been defined for kidney donors across the 3 measurements. Conclusions: These findings highlight a potential opportunity to better support the psychosocial needs of donors who experience perioperative complications in the months following donation. Trial Registration: NCT00319579 and NCT00936078. Competing Interests: Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: A.X.G. received operating grant support from the CIHR, which included partnership funding from Astellas for data collection. L.S.F. received investigator-initiated research grants from Merck and Johnson & Johnson and an educational grant from Medtronic. (© The Author(s) 2021.)
Databáze:	MEDLINE
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