Leishmaniasis: the act of transmission.

Autor: Serafim TD; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Coutinho-Abreu IV; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Dey R; Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA., Kissinger R; Visual and Medical Arts Unit, Research Technologies Branch, Rocky Mountain Laboratories, Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., Valenzuela JG; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. Electronic address: jvalenzuela@niaid.nih.gov., Oliveira F; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. Electronic address: loliveira@niaid.nih.gov., Kamhawi S; Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. Electronic address: skamhawi@niaid.nih.gov.
Jazyk: angličtina
Zdroj: Trends in parasitology [Trends Parasitol] 2021 Nov; Vol. 37 (11), pp. 976-987. Date of Electronic Publication: 2021 Aug 10.
DOI: 10.1016/j.pt.2021.07.003
Abstrakt: The contribution of vector transmission to pathogen establishment is largely underrated. For Leishmania, transmission by sand flies is critical to early survival involving an irreproducible myriad of parasite, vector, and host molecules acting in concert to promote infection at the bite site. Here, we review recent breakthroughs that provide consequential insights into how vector transmission of Leishmania unfolds. We focus on recent work pertaining to the effect of gut microbiota, sand fly immunity, and changes in metacyclogenesis upon multiple blood meals, on Leishmania development and transmission. We also explore how sand fly saliva, egested parasite molecules and vector gut microbiota, and bleeding have been implicated in modulating the early innate host response to Leishmania, affecting the phenotype of neutrophils and monocytes arriving at the bite site.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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