Hydrops fetalis-trends in associated diagnoses and mortality from 1997-2018.

Autor: Tolia VN; The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL, USA. Veeral.tolia@bswhealth.org.; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center, Dallas, TX, USA. Veeral.tolia@bswhealth.org.; Pediatrix Medical Group, Dallas, TX, USA. Veeral.tolia@bswhealth.org., Hunter Clark R Jr; University of South Carolina School of Medicine Greenville, Greenville, SC, USA., Perelmuter B; Pediatrix Medical Group, Dallas, TX, USA., Frankfurt JA; Pediatrix Medical Group, Dallas, TX, USA., Ahmad KA; The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL, USA.; Baylor College of Medicine, San Antonio, TX, USA.; Pediatrix Medical Group of San Antonio, San Antonio, TX, USA., Abrams ME; Obstetrix Medical Group of Phoenix Neonatology, Phoenix, AZ, USA., Cohen JL; Division of Medical Genetics, Department of Pediatrics, Duke University, Durham, NC, USA., Clark RH; The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2021 Oct; Vol. 41 (10), pp. 2537-2543. Date of Electronic Publication: 2021 Aug 12.
DOI: 10.1038/s41372-021-01179-3
Abstrakt: Objectives: To describe and evaluate trends in the etiology and mortality risk in neonates admitted for neonatal intensive care with hydrops fetalis.
Study Design: A retrospective review of de-identified patient data in the Pediatrix Clinical Data Warehouse from 1997 to 2018.
Results: We identified 2144 infants diagnosed with hydrops fetalis. The most common diagnoses were congenital heart disease (n = 325, 15.2%), genetic diagnoses (n = 269, 12.5%) and cardiac arrhythmia (n = 176, 8.2%). Of 2144 neonates, 988 (46%) survived to hospital discharge and 775 (36%) died prior to discharge. Mortality rate was highly variable across diagnoses, ranging from 90% in infants with congenital diaphragmatic hernia to 0% in infants with atrial flutter. Over the study period, more infants were diagnosed with trisomies and fewer with twin-to-twin transfusion. Mortality decreased by 5% from 1997-2007 to 2008-2018.
Conclusions: The risk of death among neonates with hydrops fetalis is highly dependent on the underlying cause, with increasing risk of mortality at lower gestational ages.
(© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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