Decreased convulsive threshold and memory loss after anti-NMDAR positive CSF injection in zebrafish.

Autor: Goi LDS; Neuroinflammation and Neuroimmunology Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; School of Medicine, Graduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil., Altenhofen S; School of Sciences, Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; Neurochemistry and Psychopharmacology Laboratory, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil., Nabinger DD; School of Sciences, Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; Neurochemistry and Psychopharmacology Laboratory, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil., Bonan CD; School of Medicine, Graduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; School of Sciences, Graduate Program in Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; Neurochemistry and Psychopharmacology Laboratory, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil., Sato DK; Neuroinflammation and Neuroimmunology Laboratory, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil; School of Medicine, Graduate Program in Medicine and Health Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil. Electronic address: douglas.sato@pucrs.br.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2021 Oct 15; Vol. 359, pp. 577689. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1016/j.jneuroim.2021.577689
Abstrakt: Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis initially promotes memory deficits, behavioral changes, and epileptic seizures. We developed a new animal model of anti-NMDAR encephalitis using a single cerebroventricular injection of CSF from patients in adult zebrafish. We observed a reduction of the seizure threshold and recent memory deficits in those animals injected with CSF from patients with anti-NMDAR encephalitis. The locomotor activity was similar in the CSF and control groups. This zebrafish model consistently recapitulates symptoms seen in patients with anti-NMDAR encephalitis. It may provide a reliable, fast and cost-effective platform to investigate new therapeutic strategies to anti-NMDAR encephalitis.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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