Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury.

Autor:	Lukoyanov N; Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, Porto, Portugal., Watanabe H; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Carvalho LS; Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, Porto, Portugal., Kononenko O; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Sarkisyan D; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Zhang M; Neuronano Research Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Andersen MS; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Lukoyanova EA; Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Instituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, Porto, Portugal., Galatenko V; Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, Russian Federation., Tonevitsky A; Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow, Russian Federation.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russian Federation., Bazov I; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Iakovleva T; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Schouenborg J; Neuronano Research Center, Department of Experimental Medical Science, Lund University, Lund, Sweden., Bakalkin G; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Aug 10; Vol. 10. Date of Electronic Publication: 2021 Aug 10.
DOI:	10.7554/eLife.65247
Abstrakt:	Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expression patterns in the lumbar spinal cord. The injury-induced postural effects were abolished by hypophysectomy and were mimicked by transfusion of serum from animals with brain injury. Administration of the pituitary neurohormones β-endorphin or Arg-vasopressin-induced side-specific hindlimb responses in naive animals, while antagonists of the opioid and vasopressin receptors blocked hindlimb postural asymmetry in rats with brain injury. Thus, in addition to the well-established involvement of motor pathways descending from the brain to spinal circuits, the side-specific humoral signaling may also add to postural and reflex asymmetries seen after brain injury. Competing Interests: NL, HW, LC, OK, DS, MZ, MA, EL, AT, IB, TI, JS, GB No competing interests declared, VG Vladimir Galatenko is affiliated with Evotec International GmbH. The author has no other competing interests to declare. (© 2021, Lukoyanov et al.)
Databáze:	MEDLINE
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