The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge.

Autor:	Yan YY; School of Medicine, Shanxi Datong University, Datong, China., Zhou WM; Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Wang YQ; Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Guo QR; Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.; Xinjiang Institute of Materia Medica, Urumqi, China., Zhao FX; School of Medicine, Shanxi Datong University, Datong, China., Zhu ZY; School of Medicine, Shanxi Datong University, Datong, China., Xing YX; School of Medicine, Shanxi Datong University, Datong, China., Zhang HY; School of Medicine, Shanxi Datong University, Datong, China., Aljofan M; Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan., Jarrahi AM; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Makabel B; Xinjiang Institute of Materia Medica, Urumqi, China., Zhang JY; Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2021 Jul 21; Vol. 8, pp. 699929. Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021).
DOI:	10.3389/fmolb.2021.699929
Abstrakt:	SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Yan, Zhou, Wang, Guo, Zhao, Zhu, Xing, Zhang, Aljofan, Jarrahi, Makabel and Zhang.)
Databáze:	MEDLINE
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