The role of 25-hydroxyvitamin-D3 and vitamin D receptor gene in human periodontal ligament fibroblasts as response to orthodontic compressive strain: an in vitro study.
Autor: | Küchler EC; Department of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Schröder A; Department of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Teodoro VB; Private Practice Curitiba, Paraná, Brazil., Nazet U; Department of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Scariot R; Department of Stomatology, Federal University of Paraná, Curitiba, Paraná, Brazil., Spanier G; Department of Maxillofacial Surgery, University of Regensburg, Regensburg, Germany., Proff P; Department of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany., Kirschneck C; Department of Orthodontics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. christian.kirschneck@klinik.uni-regensburg.de. |
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Jazyk: | angličtina |
Zdroj: | BMC oral health [BMC Oral Health] 2021 Aug 06; Vol. 21 (1), pp. 386. Date of Electronic Publication: 2021 Aug 06. |
DOI: | 10.1186/s12903-021-01740-8 |
Abstrakt: | Background: This study aimed to investigate, if different physiological concentrations of vitamin D (25(OH)D Methods: A pool of hPDL fibroblasts was treated in absence or presence of 25(OH)D Results: RANKL, RANKL:OPG ratio, COX-2, IL-6, DHCR7, CYP2R1 and AMDHD1 were differentially expressed during simulated orthodontic compressive strain (p < 0.05). The RANKL:OPG ratio was downregulated by all concentrations (10 ng/ml, 40 ng/ml and 60 ng/ml) of 25(OH)D Conclusions: Simulated orthodontic compressive strain and physiological concentrations of 25(OH)D (© 2021. The Author(s).) |
Databáze: | MEDLINE |
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