Clinical features of COVID-19 in cancer patients within Wuhan, China.

Autor:	Zhan LL; Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, China., Liu Y; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Zhang BC; Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China., Deng ZM; Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, China., Zhang L; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China., Liu H; Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, China., Yang J; Reproductive Center, Renmin Hospital of Wuhan University, Wuhan, China., Cheng YX; Department of Gynaecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, China.
Jazyk:	angličtina
Zdroj:	Annals of palliative medicine [Ann Palliat Med] 2021 Jul; Vol. 10 (7), pp. 8094-8102.
DOI:	10.21037/apm-21-1596
Abstrakt:	Background: There have been few reports on cancer patients with COVID-19 since its outbreak. Our study aimed to understand the clinical features of cancer patients with COVID-19 and determine the impact of surgery and chemotherapy on the patients' conditions. Methods: Seventy COVID-19 patients from Renmin Hospital of Wuhan University, including 18 cancer patients, were enrolled in this study. Patients were classified into moderate or severe cases of COVID-19 and as well as non-cancer or cancer patients. Cancer patients were further grouped into Group A (prevalent cases with cancer history) and Group B (incident cases who underwent cancer treatment recently). Laboratory results were analyzed to determine whether cancer-related surgery and chemotherapy worsened the condition of cancer patients. The patients presented with clinical symptoms of COVID-19, including fever, dry cough, and polypnea; blood tests also revealed decreased lymphocyte counts and cellular immune function, and examination of CT scans revealed patchy ground-glass opacity of lungs. Results: The results showed a significant difference (P<0.05) in levels of CD3 CD4 T lymphocytes and D-dimer between non-cancer and cancer patients with moderate COVID-19; there was also a significant difference (P<0.05) in levels of D-dimer between non-cancer and cancer patients with severe COVID-19. Except for liver function, there was no significant difference (P>0.05) between cancer patients in Group A and B with moderate COVID-19. A significant difference (P<0.05) in neutrophil-to-lymphocyte ratio (NLR) and CD4 T lymphocytes was observed between cancer patients with moderate COVID-19 and those with severe COVID-19. Conclusions: The results indicated that chemotherapy and surgery might not worsen the conditions of COVID-19 patients. NLR and CD4 T lymphocyte might be used as effective indicators for the conditions of cancer patients with COVID-19.
Databáze:	MEDLINE
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