Effects of Probiotics on Diarrhea and CD4 Cell Count in People Living With HIV: A Systematic Review and Meta-Analysis.

Autor:	Zhang XL; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China.; Yunnan Institute of Digestive Disease, First Affiliated Hospital of Kunming Medical University, Kunming, China., Chen MH; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China., Geng ST; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China., Yu J; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China., Kuang YQ; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China., Luo HY; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China.; Yunnan Institute of Digestive Disease, First Affiliated Hospital of Kunming Medical University, Kunming, China., Wang KH; NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China.; Yunnan Institute of Digestive Disease, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2021 Jul 19; Vol. 12, pp. 570520. Date of Electronic Publication: 2021 Jul 19 (Print Publication: 2021).
DOI:	10.3389/fphar.2021.570520
Abstrakt:	Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there is a controversy regarding the efficacy of probiotics for the treatment of AIDS. This study systematically reviewed the evidence of the effects of existing probiotic interventions on AIDS and sought to provide information on the role of probiotics in the treatment of HIV/AIDS patients. A meta-analysis of studies identified by screening multiple databases was performed using a fixed-effects model in Review Manager 5.2 software. The meta-analysis showed that probiotics could reduce the incidence of AIDS-related diarrhea (RR = 0.60 (95% CI: 0.44-0.82), p = 0.001). The short-term use of probiotics (supplementation duration shorter than 30 days) did not reduce the incidence of diarrhea (RR = 0.76 (95% CI: 0.51-1.14), p = 0.19), while the long-term use of probiotics (supplementation duration longer than 30 days) reduced diarrhea (RR = 0.47 (95% CI: 0.29-0.76), p = 0.002). Probiotics had no effect on CD4 cell counts in HIV/AIDS patients (MD = 21.24 (95% CI: -12.95-55.39), p = 0.22). Our data support that probiotics were associated with an obvious reduction in AIDS-related diarrhea, which indicates the need for additional research on this potential preventive strategy for AIDS. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Zhang, Chen, Geng, Yu, Kuang, Luo and Wang.)
Databáze:	MEDLINE
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