Antioxidant and anti-inflammatory response to curcumin supplementation in hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial.

Autor: Rodrigues HCN; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil. Electronic address: hellenchrisnutri@hotmail.com., Martins TFP; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil., Santana NCFES; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil., Braga CC; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil., Silva MAC; Center of Studies and Research Toxic-Pharmacological, Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil., Cunha LCD; Center of Studies and Research Toxic-Pharmacological, Faculty of Pharmacy, Federal University of Goias, Goiania, GO, Brazil., Sugizaki CSA; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil., Freitas ATVS; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil., Costa NA; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil., Peixoto MDRG; Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2021 Aug; Vol. 44, pp. 136-142. Date of Electronic Publication: 2021 Jun 24.
DOI: 10.1016/j.clnesp.2021.06.006
Abstrakt: Background and Objectives: Hemodialysis (HD) patients are vulnerable to malnutrition and cardiovascular complications due to many factors, including oxidative stress and inflammation. Curcumin supplementation is associated with attenuation of proinflammatory cytokines and increased activity of antioxidant enzymes, but its effects in HD patients are unknown. This study aimed to evaluate the effect of curcumin supplementation on oxidative stress and inflammation in HD patients.
Methods: This randomized, double-blind, placebo-controlled trial enrolled 43 HD patients and divided them into two groups: supplemented with curcumin (1 g/day) or placebo (corn starch) for 12 weeks. Demographic information and blood samples were taken at the start and the end of the study to determine serum malondialdehyde (MDA) concentrations, antioxidant enzyme activity, and high-sensitivity C-reactive protein (hs-CRP).
Results: The curcumin group showed a significant increase in catalase activity [Δ = 1.13 ± 2.87 versus Δ = -1.08 ± 2.68; p = 0.048] and preserved glutathione peroxidase activity [Δ = -4.23 ± 11.50 versus Δ = -14.44 ± 13.96; p < 0.01] compared with the placebo group. However, no significant changes were found in MDA concentrations, glutathione reductase activity, and hs-CRP concentrations after the intervention.
Conclusion: Curcumin supplementation for 12 weeks had potential effects on antioxidant response, but it was not enough to reduce oxidative stress markers and inflammation in HD patients. This trial was registered at EnsaiosClínicos.gov.br under registration number RBR-2t5zpd.
Competing Interests: Declaration of competing interest The authors declare that there were no conflicts of interest, and all authors participated sufficiently in the work and take public responsibility for the content of the paper. The final manuscript has been seen and approved by all authors.
(Copyright © 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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