New-Onset Diabetes with Ketoacidosis Precipitated by COVID-19 in Children: A Report of Two Cases.

Autor: Chekhlabi N; Department of Paediatrics, International University Hospital Cheikh Khalifa, Mohammed VI University of Health Sciences UM6SS, Casablanca, Morocco., Haoudar A; Department of Intensive Care Unit, International University Hospital Cheikh Khalifa, Mohammed VI University of Health Sciences UM6SS, Casablanca, Morocco., Echcharii N; Department of Paediatrics, International University Hospital Cheikh Khalifa, Mohammed VI University of Health Sciences UM6SS, Casablanca, Morocco., Ettair S; Department of Paediatrics, International University Hospital Cheikh Khalifa, Mohammed VI University of Health Sciences UM6SS, Casablanca, Morocco.; Mohamed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco., Dini N; Department of Paediatrics, International University Hospital Cheikh Khalifa, Mohammed VI University of Health Sciences UM6SS, Casablanca, Morocco.; Mohamed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco.
Jazyk: angličtina
Zdroj: Case reports in pediatrics [Case Rep Pediatr] 2021 Jul 16; Vol. 2021, pp. 5545258. Date of Electronic Publication: 2021 Jul 16 (Print Publication: 2021).
DOI: 10.1155/2021/5545258
Abstrakt: Background and Aims: There is growing evidence that the 2019 coronavirus disease (COVID-19) is emerging as a potential trigger virus for the development of diabetes mellitus in children. This can occur even in patients without factors predisposing to impaired glucose metabolism. Here, we report two rare cases of diabetic ketoacidosis revealing new-onset diabetes and precipitated by COVID-19. These cases are reported in view of their rarity and originality. The relationship between type 1 diabetes mellitus and COVID-19 is discussed.
Results: Two children developed symptoms suggestive of diabetic ketoacidosis preceded by polyuria, polydipsia, and asbestos. There is a documented COVID-19 infection in the parents of the 2 children. An asymptomatic infection was detected in the 2 patients on the basis of a reverse transcription polymerase chain reaction (RT-PCR) test. Thoracic imaging and inflammatory workup were negative in both cases. Both patients responded well to treatment, including rehydration regimens and intravenous insulin. On the 2nd day of their hospitalization, they were transferred to several injections of subcutaneous insulin with therapeutic and nutritional education from the parents. After about 4 weeks, their insulin requirements probably decreased due to the diabetes honeymoon.
Conclusion: COVID-19 can induce acute onset diabetes and diabetic ketoacidosis in children. More research data are needed to improve our knowledge of this constellation and to guide the most appropriate therapies.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2021 Nabila Chekhlabi et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje