Comparative Assessment of the Antimicrobial Efficacy of Triclosan, Amoxicillin and Eugenol against Enterococcus faecalis .

Autor:	Gowda J; Department of Paediatric Dentistry, Farooqia Dental College, Mysore, Karnataka, India., Tavarageri A; Department of Paediatric Dentistry, SDM College of Dental Sciences, Dharwad, Karnataka, India., Kulkarni R; Department of Microbiology, SDM College of Medical Sciences, Dharwad, Karnataka, India., Anegundi RT; Department of Paediatric Dentistry, SDM College of Dental Sciences, Dharwad, Karnataka, India., Janardhan A; Department of Conservative Dentistry, JSS Dental College, Mysore, Karnataka, India., Bhat MA; Department of Dentistry, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
Jazyk:	angličtina
Zdroj:	International journal of clinical pediatric dentistry [Int J Clin Pediatr Dent] 2021 Jan-Feb; Vol. 14 (1), pp. 59-62.
DOI:	10.5005/jp-journals-10005-1869
Abstrakt:	Aims: Elimination of microorganisms and prevention of recurrence of infection from the complex root canal system of primary teeth requires an obturating material with broad antimicrobial activity. Hence, the purpose of the study is to assess and compare the antimicrobial efficacy of Triclosan, Amoxicillin and Eugenol individually and in combinations against a resistant microorganism viz., Enterococcus faecalis . Materials and Methods: A two-fold serial dilution method was used to check the minimum inhibitory concentration (MIC) of triclosan, amoxicillin and eugenol against thirty E. faecalis (isolated from oral lesions). The resistant strains were subjected to different combinations of three agents by modified checkerboard method. MIC was determined after incubation for 24 hours at 370°C. Then the three dilutions from MIC were inoculated on BHI agar plates and incubated overnight to determine minimum bactericidal concentration (MBC). Results: The mean MIC and MBC of triclosan was 3.43 μg/mL and 3.75 μg/mL respectively. Whereas for amoxicillin, it was 3.43 μg/mL and 3.85 μg/mL. Eugenol did not show any inhibition up to a concentration of 3200 μg/mL. In combination, eugenol showed good synergistic effect with both triclosan and amoxicillin. In combination with triclosan, eugenol showed much promising result as compared with amoxicillin. But triclosan and amoxicillin combination showed inhibition at higher concentrations. Conclusion: Triclosan and eugenol combination showed better effectiveness against E. faecalis in comparison to amoxicillin and eugenol. Triclosan and amoxicillin showed antagonism when used in combination against E. faecalis . How to Cite This Article: Gowda J, Tavarageri A, Kulkarni R, et al. Comparative Assessment of the Antimicrobial Efficacy of Triclosan, Amoxicillin and Eugenol against Enterococcus faecalis . Int J Clin Pediatr Dent 2021;14(1):59-62. Competing Interests: Source of support: Nil Conflict of interest: None (Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.)
Databáze:	MEDLINE
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