The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity.
| Autor: | Finnie PSB; Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Avenue, Cambridge, MA 02139, USA., Komorowski RW; Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Avenue, Cambridge, MA 02139, USA., Bear MF; Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: mbear@mit.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Current biology : CB [Curr Biol] 2021 Sep 27; Vol. 31 (18), pp. 3996-4008.e6. Date of Electronic Publication: 2021 Jul 26. |
| DOI: | 10.1016/j.cub.2021.06.079 |
| Abstrakt: | The hippocampus and neocortex are theorized to be crucial partners in the formation of long-term memories. Here, we assess hippocampal involvement in two related forms of experience-dependent plasticity in the primary visual cortex (V1) of mice. Like control animals, those with hippocampal lesions exhibit potentiation of visually evoked potentials after passive daily exposure to a phase-reversing oriented grating stimulus, which is accompanied by long-term habituation of a reflexive behavioral response. Thus, low-level recognition memory is formed independently of the hippocampus. However, response potentiation resulting from daily exposure to a fixed sequence of four oriented gratings is severely impaired in mice with hippocampal damage. A feature of sequence plasticity in V1 of controls, which is absent in lesioned mice, is the generation of predictive responses to an anticipated stimulus element when it is withheld or delayed. Thus, the hippocampus is involved in encoding temporally structured experience, even within the primary sensory cortex. Competing Interests: Declaration of interests The authors declare no competing interests. R.W.K. is currently an employee of Biogen, Inc. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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