Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults.

Autor:	Ponsford MJ; Immunodeficiency Centre for Wales, University of Wales Hospital, Cardiff, UK ponsfordm@cardiff.ac.uk.; Division Infection, Immunity, and Inflammation, School of Medicine, Cardiff University, Cardiff, UK., Jefferies R; Respiratory Health Implementation Group, NHS Wales Collaborative, Swansea, UK.; Swansea University Medical School, Institute of Life Science, Swansea University, Swansea, UK., Davies C; The Institute of Clinical Science and Technology, Cardiff, UK., Farewell D; Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK., Humphreys IR; Division Infection, Immunity, and Inflammation, School of Medicine, Cardiff University, Cardiff, UK.; Systems Immunity Research Institute, Cardiff University, Cardiff, UK., Jolles S; Immunodeficiency Centre for Wales, University of Wales Hospital, Cardiff, UK., Fairbairn S; Respiratory Health Implementation Group, NHS Wales Collaborative, Swansea, UK.; Department of Respiratory Medicine, Aneurin Bevan Health Board, Newport, UK., Lewis K; Department of Medicine, Prince Philip Hospital, Hywel Dda University Health Board, Carmarthen, UK.; College of Human and Health Sciences, Swansea University, Swansea, West Glamorgan, UK., Menzies D; Department of Respiratory Medicine, Betsi Cadwaladr University Health Board, Bangor, UK., Benjamin A; Department of Respiratory Medicine, Cwm Taf University Health Board, Abercynon, UK., Thaivalappil F; Department of Respiratory Medicine, Swansea Bay University Health Board, Port Talbot, UK., Williams C; Communicable Disease Surveillance Centre, Public Health Wales, Cardiff, UK., Barry SM; Department of Respiratory Medicine, Cardiff and Vale University Health Board, Cardiff, UK.
Jazyk:	angličtina
Zdroj:	Thorax [Thorax] 2021 Dec; Vol. 76 (12), pp. 1246-1249. Date of Electronic Publication: 2021 Jul 22.
DOI:	10.1136/thoraxjnl-2021-216964
Abstrakt:	The burden of nosocomial SARS-CoV-2 infection remains poorly defined. We report on the outcomes of 2508 adults with molecularly-confirmed SARS-CoV-2 admitted across 18 major hospitals, representing over 60% of those hospitalised across Wales between 1 March and 1 July 2020. Inpatient mortality for nosocomial infection ranged from 38% to 42%, consistently higher than participants with community-acquired infection (31%-35%) across a range of case definitions. Those with hospital-acquired infection were older and frailer than those infected within the community. Nosocomial diagnosis occurred a median of 30 days following admission (IQR 21-63), suggesting a window for prophylactic or postexposure interventions, alongside enhanced infection control measures. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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