| Autor: |
Rao TN; Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India., AlOmar SY; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Ahmed F; Department of Physics, College of Science, King Faisal University, Hofuf 31982, Al-Ahsa, Saudi Arabia., Albalawi F; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Ahmad N; Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Rao NK; Department of Organic Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India., Rao MVB; Department of Organic Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India., Cheedarala RK; Department of Materials Science and Engineering, Ulsan National Institute of Science and Technology, UNIST-Gil, Ulsan 44919, Korea., Reddy GR; Department of Chemical Engineering, A.C Tech Campus, Anna University, Chennai 600025, India., Naidu TM; Department of Nuclear Physics, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India. |
| Abstrakt: |
In this article, a zirconia-based nano-catalyst (Nano-ZrO 2 ), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole drugs in a one-pot method. All synthesized materials were characterized using 1 HNMR, 13 CNMR, and LC-MS spectroscopy as well as microanalysis data. Furthermore, the synthesis of nano-ZrO 2 was processed using a standard hydrothermal technique in pure form. The crystal structure of nano-ZrO 2 and phase purity were studied, and the crystallite size was calculated from XRD analysis using the Debye-Scherrer equation. Furthermore, the antimicrobial activity of the synthesized benzimidazole drugs was evaluated in terms of Gram-positive, Gram-negative, and antifungal activity, and the results were satisfactory. |
