Pterocarpus marsupium extract extends replicative lifespan in budding yeast.

Autor: Lee MB; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Kiflezghi MG; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Tsuchiya M; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Wasko B; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.; Department of Biology and Biotechnology, University of Houston-Clear Lake, Houston, TX, USA., Carr DT; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Uppal PA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Grayden KA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Elala YC; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Nguyen TA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Wang J; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Ragosti P; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Nguyen S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Zhao YT; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.; Department of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA., Kim D; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Thon S; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Sinha I; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Tang TT; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Tran NHB; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Tran THB; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Moore MD; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Li MAK; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA., Rodriguez K; Department of Cell Systems and Anatomy, University of Texas Health Sciences Center, San Antonio, TX, USA.; Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA., Promislow DEL; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA.; Department of Biology, University of Washington, Seattle, WA, USA., Kaeberlein M; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Box 357470, Seattle, WA, 98195-7470, USA. kaeber@uw.edu.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2021 Oct; Vol. 43 (5), pp. 2595-2609. Date of Electronic Publication: 2021 Jul 23.
DOI: 10.1007/s11357-021-00418-x
Abstrakt: As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has served as a premier model organism for identifying genetic and molecular factors that modulate cellular aging and is a powerful system in which to evaluate candidate longevity interventions. Here we screened a collection of natural products and natural product mixtures for effects on the growth rate, mTOR-mediated growth inhibition, and replicative lifespan. No mTOR inhibitory activity was detected, but several of the treatments affected growth rate and lifespan. The strongest lifespan shortening effects were observed for green tea extract and berberine. The most robust lifespan extension was detected from an extract of Pterocarpus marsupium and another mixture containing Pterocarpus marsupium extract. These findings illustrate the utility of the yeast system for longevity intervention discovery and identify Pterocarpus marsupium extract as a potentially fruitful longevity intervention for testing in higher eukaryotes.
(© 2021. American Aging Association.)
Databáze: MEDLINE
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