Stem Cell Therapy in Dengue Virus-Infected BALB/C Mice Improves Hepatic Injury.

Autor:	Sakinah S; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Priya SP; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Mok PL; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakakah, Saudi Arabia.; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Munisvaradass R; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Teh SW; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Sun Z; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Alzahrani B; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakakah, Saudi Arabia., Abu Bakar F; Bioinformatics and Computational Biology, Malaysia Genome Institute, National Institute of Biotechnology Malaysia (NIBM), Kajang, Malaysia., Chee HY; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Awang Hamat R; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., He G; Institute of Health, Kunming Medical University, Kunming, China., Xiong C; Department of Medical Microbiology, School of Public Health, Fudan University, Shanghai, China., Joseph N; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Tong JB; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia., Wu X; First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China., Maniam M; Sultan Idris Education University, Tanjong Malim, Malaysia., Samrot AV; School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Malaysia., Higuchi A; Department of Chemical and Materials Engineering, National Central University, Taoyuan City, Taiwan.; R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan City, Taiwan., Kumar SS; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri Kembangan, Malaysia.; Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai, India.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Jul 05; Vol. 9, pp. 637270. Date of Electronic Publication: 2021 Jul 05 (Print Publication: 2021).
DOI:	10.3389/fcell.2021.637270
Abstrakt:	Extensive clinical efforts have been made to control the severity of dengue diseases; however, the dengue morbidity and mortality have not declined. Dengue virus (DENV) can infect and cause systemic damage in many organs, resulting in organ failure. Here, we present a novel report showing a tailored stem-cell-based therapy that can aid in viral clearance and rescue liver cells from further damage during dengue infection. We administered a combination of hematopoietic stem cells and endothelial progenitor cells in a DENV-infected BALB/c mouse model and found that delivery of this cell cocktail had improved their liver functions, confirmed by hematology, histopathology, and next-generation sequencing. These stem and progenitor cells can differentiate into target cells and repair the damaged tissues. In addition, the regime can regulate endothelial proliferation and permeability, modulate inflammatory reactions, enhance extracellular matrix production and angiogenesis, and secrete an array of growth factors to create an enhanced milieu for cell reparation. No previous study has been published on the treatment of dengue infection using stem cells combination. In conclusion, dengue-induced liver damage was rescued by administration of stem cell therapy, with less apoptosis and improved repair and regeneration in the dengue mouse model. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer RR declared a shared affiliation, with no collaboration, with one of the authors, AH, to the handling editor at the time of the review. (Copyright © 2021 Sakinah, Priya, Mok, Munisvaradass, Teh, Sun, Alzahrani, Abu Bakar, Chee, Awang Hamat, He, Xiong, Joseph, Tong, Wu, Maniam, Samrot, Higuchi and Kumar.)
Databáze:	MEDLINE
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