Effects of combined exposure to modeled radiation and gravitation factors of the interplanetary flight: Monkeys' cognitive functions and the content of monoamines and their metabolites; cytogenetic changes in peripheral blood lymphocytes.

Autor: Belyaeva AG; Institute of Biomedical Problems of the Russian Academy of Sciences (RAS), 123007, Moscow, Russian Federation. Electronic address: yasya_bi@mail.ru., Kudrin VS; Institute of Biomedical Problems of the Russian Academy of Sciences (RAS), 123007, Moscow, Russian Federation; Zakusov Institute of Pharmacology, 125315, Moscow, Russian Federation. Electronic address: kudrinvs@mail.ru., Koshlan IV; Joint Institute for Nuclear Research 141980, Dubna, Moscow Oblast, Russian Federation; Dubna State University, 141982, Dubna, Moscow Oblast, Russian Federation. Electronic address: koshlan@jinr.ru., Koshlan NA; Joint Institute for Nuclear Research 141980, Dubna, Moscow Oblast, Russian Federation. Electronic address: nkoshlan@jinr.ru., Isakova MD; Joint Institute for Nuclear Research 141980, Dubna, Moscow Oblast, Russian Federation; Dubna State University, 141982, Dubna, Moscow Oblast, Russian Federation. Electronic address: m.isackowa2010@yandex.ru., Bogdanova YV; Joint Institute for Nuclear Research 141980, Dubna, Moscow Oblast, Russian Federation. Electronic address: jules@li.ru., Timoshenko GN; Joint Institute for Nuclear Research 141980, Dubna, Moscow Oblast, Russian Federation; Dubna State University, 141982, Dubna, Moscow Oblast, Russian Federation. Electronic address: tim@jinr.ru., Krasavin EA; Joint Institute for Nuclear Research 141980, Dubna, Moscow Oblast, Russian Federation; Dubna State University, 141982, Dubna, Moscow Oblast, Russian Federation. Electronic address: krasavin@jinr.ru., Blokhina TM; State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098, Moscow, Russian Federation; Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russian Federation. Electronic address: tai2509@yandex.ru., Yashkina EI; State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098, Moscow, Russian Federation., Osipov AN; State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098, Moscow, Russian Federation; Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Region, Russian Federation. Electronic address: andreyan.osipov@gmail.com., Nosovsky AN; Institute of Biomedical Problems of the Russian Academy of Sciences (RAS), 123007, Moscow, Russian Federation. Electronic address: nam@imbp.ru., Perevezentsev AA; Institute of Biomedical Problems of the Russian Academy of Sciences (RAS), 123007, Moscow, Russian Federation. Electronic address: perezx@me.com., Shtemberg AS; Institute of Biomedical Problems of the Russian Academy of Sciences (RAS), 123007, Moscow, Russian Federation. Electronic address: andrei_shtemberg@mail.ru.
Jazyk: angličtina
Zdroj: Life sciences in space research [Life Sci Space Res (Amst)] 2021 Aug; Vol. 30, pp. 45-54. Date of Electronic Publication: 2021 May 27.
DOI: 10.1016/j.lssr.2021.05.004
Abstrakt: In a study on primates (Macaca mulatta), neurobiological and radiobiological effects have been studied of the synchronous combined action of 7-day antiorthostatic hypokinesia and exposure of the monkeys' head first to γ-rays during 24 h and then to accelerated 12 C ions. The neurobiological effects were evaluated by the cognitive functions which model the basic elements of operator activity and the concentration of monoamines and their metabolites in peripheral blood. The radiobiological effects were evaluated by the chromosomal aberration and DNA double-strand break (DSB) yield in peripheral blood lymphocytes. The results of the cognitive function research show that the typological features of the animals' higher nervous activity are the prevailing factor that determines changes in these functions. The monkey of the strong balanced type effectively retained its cognitive functions after the exposures, while in the weak unbalanced type animals these functions were impaired. These changes went along with a decrease in the concentration of monoamines and their metabolites and an increase in the DNA DSB and chromosomal aberration yield in lymphocytes.
(Copyright © 2021 The Committee on Space Research (COSPAR). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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