Acute effect of pseudoephedrine on macular microcirculation in healthy subjects: an optical coherence tomography angiography study.

Autor: Tuncer I; Alfa Medical Center, 6244 St. No:1, Bornova, 35040, Izmir, Turkey. ibrahimtuncer106@gmail.com., Unsal U; West Eye Center, Izmir, Turkey.
Jazyk: angličtina
Zdroj: Japanese journal of ophthalmology [Jpn J Ophthalmol] 2022 Jan; Vol. 66 (1), pp. 94-100. Date of Electronic Publication: 2021 Jul 19.
DOI: 10.1007/s10384-021-00859-z
Abstrakt: Purpose: To quantitatively evaluate the acute effects of pseudoephedrine on the macular microvasculature using optical coherence tomography angiography (OCTA).
Study Design: Randomized placebo-controlled clinical study.
Methods: In this study, 60 right eyes of 60 healthy subjects were divided into 2 groups. The study group received 60 mg of pseudoephedrine and the control group received a placebo. All participants underwent OCTA at baseline and 1 h after oral intake. Superficial macular flow area, foveal avascular zone (FAZ), superficial macular vessel density, central foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) were analyzed.
Results: Baseline superficial macular flow area, FAZ area, superficial macular vessel density, CFT and SFCT measurements in the study and control groups showed no significant difference (p > 0.05 for all). Oral pseudoephedrine intake caused a significant reduction in superficial macular flow area, FAZ area, superficial macular vessel density and SFCT measurements when compared with baseline (p < 0.05 for all). However, there was no significant difference in CFT after oral pseudoephedrine intake (p > 0.05).
Conclusion: Oral pseudoephedrine intake causes a significant decrease in superficial macular blood flow and SFCT. Impairmant of macular microcirculation can be detected noninvasively and quantitavitely by OCTA.
(© 2021. Japanese Ophthalmological Society.)
Databáze: MEDLINE
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