The connection between rs6265 polymorphism in the BDNF gene and successful mastering of the video-oculographic interface.

Autor:	Turovsky YA; Laboratory of Medical Cybernetics, Voronezh State University, 394018 Voronezh, Russia.; V. A. Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, 117997 Moscow, Russia., Gureev AP; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Vitkalova IY; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Popov VN; Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.; Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia., Vakhtin AA; Department of Programming and Information Technologies, Voronezh State University, 394018 Voronezh, Russia.
Jazyk:	angličtina
Zdroj:	Journal of integrative neuroscience [J Integr Neurosci] 2021 Jun 30; Vol. 20 (2), pp. 287-296.
DOI:	10.31083/j.jin2002028
Abstrakt:	A video-oculographic interface is a system for controlling objects using eye movements. The video-oculographic interface differs from other brain-computer interfaces regarding its improved accuracy, simplicity, and ergonomics. Despite these advantages, all users are not equally successful in mastering these various devices. It has been suggested that the genetic characteristics of the operators may determine the efficiency of video-oculographic interface mastery. We recruited healthy users with rs6313, rs2030324, rs429358, rs10119, rs457062, rs4290270, and rs6265 polymorphisms and analyzed the relationships between these polymorphisms and values of success in video-oculographic interface mastery. We found that carriers of the G/G genotype of the rs6265 polymorphism ( BDNF gene) demonstrated the best results in video-oculographic interface mastery. In contrast, carriers of the A/A genotype were characterized by large standard deviations in the average amplitude of eye movement and the range of eye movement negatively correlated with goal achievement. This can be explained through the fact that carriers of the A/A genotype demonstrate lower synaptic plasticity due to reduced expression of BDNF when compared to carriers of the G/G genotype. These results expand our understanding of the genetic predictors of successful video-oculographic interface management, which will help to optimize device management training for equipment operators and people with disabilities. Competing Interests: Given his role as the Review Board Member of JIN, Dr. Artem P. Gureev had no involvement in the peer-review of this article and has no access to information regarding its peer-review. (© 2021 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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