Delayed reduction of Anaplasma marginale parasitemia and packed cell volume normalization despite prolonged enrofloxacin treatment of cattle co-infected with Trypanosoma vivax.

Autor: Bastos TSA; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Cruvinel LB; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Ferreira LL; Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Nicaretta JE; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Couto LFM; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Zapa DMB; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., de Assis Cavalcante AS; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Heller LM; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Salvador VF; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Leal LLLL; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., de Morais IML; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil., Soares VE; Universidade Brasil, Descalvado, São Paulo, Brazil., Cadioli FA; Departamento de ClínicaCirurgia E Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista - Unesp, Araçatuba, Brazil., Lopes WDZ; Escola de Veterinária E Zootecnia, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. wdzlopes@hotmail.com.; Departamento de Biociências E Tecnologia Instituto de Patologia Tropical E Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. wdzlopes@hotmail.com.
Jazyk: angličtina
Zdroj: Parasitology research [Parasitol Res] 2021 Aug; Vol. 120 (8), pp. 2929-2937. Date of Electronic Publication: 2021 Jul 12.
DOI: 10.1007/s00436-021-07226-4
Abstrakt: Although co-infections of Trypanosoma vivax, Anaplasma spp., and Babesia spp. have been reported, knowledge gaps remain that need to be addressed. The present study evaluated the efficacy of enrofloxacin (7.5 mg/kg) against A. marginale in naturally infected cattle and cattle experimentally co-infected with T. vivax by observation of the variation in A. marginale parasitemia and packed cell volume (PCV) for 39 days. Bovines were distributed into two groups, each with six calves: T01 = animals immunosuppressed with dexamethasone and with latent anaplasmosis; T02 = animals immunosuppressed with dexamethasone, with latent anaplasmosis and experimentally co-infected with T. vivax on day 0 (D0). Animals of both groups were immunosuppressed with dexamethasone and received enrofloxacin (7.5 mg/kg) whenever mean values of parasitemia for A. marginale were ≥ 5% per group. Cattle of group T02 were also treated with isometamidium chloride (0.5 mg/kg) on D25. On D17 and D22 to D28 of the study, there was a higher (P ≤ 0.05) A. marginale parasitemia in animals of T02 than in those of T01. Animals of T01 required one enrofloxacin treatment to decrease A. marginale parasitemia, while those from T02 needed five treatments. From D5 to D37 of study, the mean values of PCV for calves from T02 were lower (P ≤ 0.05) than that for calves from T01. In conclusion, bovines co-infected T. vivax needed four more treatments with enrofloxacin to reduce A. marginale parasitemia and keep PCV values within reference standards.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: