Health care worker seromonitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration.

Autor:	Gouma S; Department of Microbiology., Weirick ME; Department of Microbiology., Bolton MJ; Department of Microbiology., Arevalo CP; Department of Microbiology., Goodwin EC; Department of Microbiology., Anderson EM; Department of Microbiology., McAllister CM; Department of Microbiology., Christensen SR; Department of Microbiology., Dunbar D; Division of Infectious Diseases., Fiore D; Department of Psychiatry., Brock A; Institute for Translational Medicine and Therapeutics, and., Weaver J; Institute for Translational Medicine and Therapeutics, and., Millar J; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., DerOhannessian S; Institute for Translational Medicine and Therapeutics, and.; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Unit TUCP; The UPenn COVID Processing Unit is detailed in Supplemental Acknowledgments., Frank I; Division of Infectious Diseases., Rader DJ; Institute for Translational Medicine and Therapeutics, and.; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wherry EJ; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hensley SE; Department of Microbiology.
Jazyk:	angličtina
Zdroj:	JCI insight [JCI Insight] 2021 Aug 23; Vol. 6 (16). Date of Electronic Publication: 2021 Aug 23.
DOI:	10.1172/jci.insight.150449
Abstrakt:	Some studies suggest that recent common coronavirus (CCV) infections are associated with reduced COVID-19 severity upon SARS-CoV-2 infection. We completed serological assays using samples collected from health care workers to identify antibody types associated with SARS-CoV-2 protection and COVID-19 symptom duration. Rare SARS-CoV-2 cross-reactive antibodies elicited by past CCV infections were not associated with protection; however, the duration of symptoms following SARS-CoV-2 infections was significantly reduced in individuals with higher common betacoronavirus (βCoV) antibody titers. Since antibody titers decline over time after CCV infections, individuals in our cohort with higher βCoV antibody titers were more likely recently infected with common βCoVs compared with individuals with lower antibody titers. Therefore, our data suggest that recent βCoV infections potentially limit the duration of symptoms following SARS-CoV-2 infections through mechanisms that do not involve cross-reactive antibodies. Our data are consistent with the emerging hypothesis that cellular immune responses elicited by recent common βCoV infections transiently reduce symptom duration following SARS-CoV-2 infections.
Databáze:	MEDLINE
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