| Autor: |
Chagomerana MB; 156288UNC Project-Malawi, Lilongwe, Malawi.; Department of Medicine, 6797University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hosseinipour MC; 156288UNC Project-Malawi, Lilongwe, Malawi.; Department of Medicine, 6797University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pilotto JH; 37903Hospital Geral de Nova Iguacu and Laboratorio de AIDS e Imunologia Molecular-IOC/Fiocruz, Rio de Janeiro, Brazil., Badal-Faesen S; Clinical HIV Research Unit, Faculty of Health Sciences, 37707University of the Witwatersrand, Johannesburg, South Africa., Nyirenda M; Johns Hopkins Project, 37610University of Malawi College of Medicine, Blantyre, Malawi., Shava E; 292006Botswana Harvard Aids Institute Partnership, Gaborone, Botswana., Godbole SV; CMR-National AIDS Research Institute, Pune, India., Akelo V; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya., Chariyalertsak S; Research Institute for Health Sciences, 26682Chiang Mai University, Chiang Mai, Thailand.; Faculty of Public Health, 26682Chiang Mai University, Suthep, Thailand., Panchia R; Perinatal HIV Research Unit, 196579University of the Witwatersrand, Soweto HPTN CRS, Soweto, South Africa., Cohen M; Department of Medicine, 6797University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
| Abstrakt: |
Sexually transmitted infections (STIs) remain a public health concern because of their interaction(s) with HIV. In the HPTN 052 study, STIs were evaluated in both HIV-positive index cases and their HIV-negative partners at enrollment and at yearly follow-up visits. Our definition for STI was based on any infection with Chlamydia trachomatis, Neisseria gonorrhoeae , syphilis, or Trichomonas vaginalis. We used log-binomial regression models to identify factors associated with prevalent STIs. Generalized estimating equation models with the Poisson distribution were used to compare STI incidence between HIV-positive index cases and HIV-negative partners. 8.1% of the participants had STIs at enrollment. The prevalence of STIs (8.9 vs. 7.2) was higher in HIV-positive index cases than HIV-negative partners. Being female (prevalence ratio (PR) = 1.61; 95% CI: 1.20-2.16) or unmarried (PR = 1.92; 95% CI: 1.17-3.14) was associated with prevalent STIs. Compared to HIV-negative male partners, HIV-positive female index cases had a higher risk of STI acquisition (incidence rate ratio (IRR) = 2.25; 95% CI: 1.70-2.97). While we are implementing HIV prevention interventions for HIV-negative people, we should also intensify targeted STI prevention interventions, especially among HIV-positive women. |
