Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E.

Autor: Lima-Antoine L; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil.; Sorbonne Université, Inserm UMRS_938, Centre de Recherche Saint-Antoine, Paris, France., de Sousa Alves Neri JL; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., de Melo TCT; Laboratory of Bioanalysis and Molecular Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil., Leite ISF; Laboratory of Bioanalysis and Molecular Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil., da Costa Santos DM; Postgraduate Program of genetics and molecular biology, Federal University of Pará, Belém, Brazil., de Araújo JNG; Northeast Biotechnology Network (RENORBIO), Graduate Program in Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil., da Costa Lemos Silva AG; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., de Araújo NK; Postgraduate Program of Healthy Sciences, Federal University of Rio Grande do Norte, Natal, Brazil., de Oliveira Ramos CC; Division of Pathology, Hospital Liga Norte Riograndense Contra o Câncer, Natal, Brazil., de Miranda Henriques Tarrapp SR; Division of Head and Neck Surgery, Liga Norte Riograndense Contra o Câncer Hospital, Natal, Brazil., Luchessi AD; Northeast Biotechnology Network (RENORBIO), Graduate Program in Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil.; Postgraduate Program of Healthy Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil., de Oliveira Lyra C; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., da Silva Ribeiro KD; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., Silbiger VN; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br.; Northeast Biotechnology Network (RENORBIO), Graduate Program in Biotechnology, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br.; Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br.; Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil. viviansilbiger@ufrn.edu.br.
Jazyk: angličtina
Zdroj: European journal of clinical nutrition [Eur J Clin Nutr] 2022 Mar; Vol. 76 (3), pp. 469-476. Date of Electronic Publication: 2021 Jul 06.
DOI: 10.1038/s41430-021-00976-5
Abstrakt: Background/objectives: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients.
Subjects/methods: We applied a cross-sectional study (2017-2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24-hr dietary recalls.
Results: Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis.
Conclusions: A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients.
(© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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