Prospection of plasma proteins as biomarkers for diabetes mellitus monitoring.
Autor: | de Paula Silva L; Graduate Program in Pharmaceutical Science, Department of Clinical Analysis, Federal University of Paraná, Rua Prefeito Lothário Meissner, 632, Curitiba, PR 80210-170 Brazil., de Moraes Rego FG; Graduate Program in Pharmaceutical Science, Department of Clinical Analysis, Federal University of Paraná, Rua Prefeito Lothário Meissner, 632, Curitiba, PR 80210-170 Brazil., Picheth G; Graduate Program in Pharmaceutical Science, Department of Clinical Analysis, Federal University of Paraná, Rua Prefeito Lothário Meissner, 632, Curitiba, PR 80210-170 Brazil., Müller-Santos M; Graduate Program in Sciences - Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba, PR Brazil., Alberton D; Graduate Program in Pharmaceutical Science, Department of Clinical Analysis, Federal University of Paraná, Rua Prefeito Lothário Meissner, 632, Curitiba, PR 80210-170 Brazil. |
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Jazyk: | angličtina |
Zdroj: | Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2021 Mar 29; Vol. 20 (1), pp. 611-620. Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021). |
DOI: | 10.1007/s40200-021-00788-1 |
Abstrakt: | Purpose: This prospective study aimed to detect and identify plasma proteins differentially expressed between groups of Brazilian diagnosed with type 1 (T1DM), type 2 (T2DM) diabetes with good and poor glycemic control and the non-diabetic group denominated control group (CG). Methods: Patients with T1DM and T2DM were subdivided according to their glycated haemoglobin (HbA Results: Alpha 2 - Macroglobulin (AMG) was 1.3-fold more abundant in T1DM with HbA Conclusion: In summary, three positive acute-phase proteins, AMG, Cp and Hp were more abundant in diabetic individuals regardless of the diabetes type. The highest Hp abundance in both types of DM with HbA Competing Interests: Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest. (© Springer Nature Switzerland AG 2021.) |
Databáze: | MEDLINE |
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