Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review.

Autor:	Emeribe AU; Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Nigeria., Abdullahi IN; Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria. inabdullahi@abu.edu.ng., Isong IK; Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Nigeria., Emeribe AO; Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Nigeria., Nwofe JO; Department of Medical Laboratory Science, Ebonyi State University, Abakaliki, Nigeria., Shuaib BI; Antiretroviral Therapy Laboratory, Ahmadu Bello University Teaching hospital, Zaria, Nigeria., Gwarzo AM; Department of Medical Microbiology and Parasitology, Federal University, Dutse, Nigeria., Usman Y; Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria., Sadi M; Institute of Veterinary Sciences, University of Saad Dahlab Blida1, Blida, Algeria.; Laboratory of Biotechnology Related to Animals Reproduction, Blida, Algeria., Umeozuru CM; Nigeria Field Epidemiology and Laboratory Training Programme, African Field Epidemiology Network, Abuja, Nigeria., Dangana A; Department of Medical Laboratory Services, University of Abuja Teaching hospital, Gwagwalada, Abuja, Nigeria., Egenti BN; Department of Community Medicine, University of Abuja, Gwagalada, Abuja, Nigeria., Mallam MAB; Department of Nursing Science, Maryam Abacha American university of Niger, Maradi, Niger Republic., Emelonye AU; Department of Nursing Science, Maryam Abacha American university of Niger, Maradi, Niger Republic., Aminu MS; Department of Nursing Science, Maryam Abacha American university of Niger, Maradi, Niger Republic., Yahaya H; Department of Nursing Science, Maryam Abacha American university of Niger, Maradi, Niger Republic., Oyewusi S; Department of Nursing Science, Maryam Abacha American university of Niger, Maradi, Niger Republic.
Jazyk:	angličtina
Zdroj:	Infection & chemotherapy [Infect Chemother] 2021 Jun; Vol. 53 (2), pp. 284-299.
DOI:	10.3947/ic.2020.0142
Abstrakt:	Backround: Data on Dengue virus (DENV) infection prevalence, geographic distribution and risk factors are necessary to direct appropriate utilization of existing and emerging control strategies. This study aimed to determine the pooled prevalence, risk factors of DENV infection and the circulating serotypes within Nigeria from January 1, 2009 to December 31, 2020. Materials and Methods: Twenty-one studies out of 2,215 available articles were eligible and included for this systematic review. Relevant articles were searched, screened and included in this study according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The risk of bias in primary studies was assessed by Cochrane's method. Heterogeneity of pooled prevalence was calculated using the chi-square test on Cochrane's Q statistic, which was quantified by I-square values. The random-effects analyses of proportions were used to determine the pooled prevalence of DENV antibodies, antigen and RNA from eligible studies. Results: Of these, 3 studies reported co-circulation of all the 4 serotypes, while 2 separately reported co-circulation of DENV-1 &2 and DENV-1 to -3. All the antibody-based studies had significantly high heterogeneity (I² >90%, P <0.05), while the NS1 and PCR-based studies had low heterogeneity (I² <25%, P >0.05). The pooled prevalence of DENV IgM, IgG, RNA, NS1 and neutralizing antibodies were 16.8%, 34.7%, 7.7%, 7.7% and 0.7%, respectively. South-east Nigeria had the highest pooled DENV-IgG seropositivity, 77.1%. Marital status, gender, educational level and occupation status, the proximity of residence to refuse dumpsite, frequent use of trousers and long sleeve shirts were significantly associated with DENV IgG seropositivity ( P <0.05). Conclusion: Based on these findings, it can be inferred that Nigeria is hyperendemic for Dengue fever and needs concerted efforts to control its spread within and outside the country. Competing Interests: No conflicts of interest. (Copyright © 2021 by The Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, and The Korean Society for AIDS.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF