Step on the cGAS! Viral inhibition of cGAS phase separation with cytosolic DNA.
| Autor: | Minhas S; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, 63100, USA; Center for Science and Engineering Living Systems (CSELS), Washington University, St. Louis, MO 63130, USA., Holehouse AS; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, 63100, USA; Center for Science and Engineering Living Systems (CSELS), Washington University, St. Louis, MO 63130, USA. Electronic address: alex.holehouse@wustl.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2021 Jul 01; Vol. 81 (13), pp. 2688-2689. |
| DOI: | 10.1016/j.molcel.2021.06.007 |
| Abstrakt: | Xu et al. (2021) uncover a conserved viral mechanism to subvert the innate immune system whereby herpesvirus tegument proteins suppress cGAS:DNA phase separation. Competing Interests: Declaration of interests A.S.H. is a scientific advisor for Dewpoint Therapeutics. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|