Subclinical Choroidal Inflammation Revealed by Indocyanine Green Angiography in Tubulointerstitial Nephritis and Uveitis Syndrome.

Autor: Scifo L; Department of Ophthalmology, CHU St-Pierre, Université Libre de Bruxelles, Brussels, Belgium.; Department of Ophthalmology, Hôpital Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Willermain F; Department of Ophthalmology, CHU St-Pierre, Université Libre de Bruxelles, Brussels, Belgium.; Department of Ophthalmology, Hôpital Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Postelmans L; Department of Ophthalmology, Hôpital Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Pozdzik A; Department of Nephrology and Dialysis, Hôpital Brugmann, Université Libre de Bruxelles, Brussels, Belgium., Lolin Sekelj K; Department of Pediatric Nephrology, Hôpital Universitaire des Enfants - Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium., Zampieri M; Department of Pediatrics, CHU St-Pierre, Université Libre de Bruxelles, Brussels, Belgium., de Jong C; Department of Ophthalmology, Hôpital Universitaire des Enfants - Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium., Makhoul D; Department of Ophthalmology, CHU St-Pierre, Université Libre de Bruxelles, Brussels, Belgium.; Department of Ophthalmology, Hôpital Brugmann, Université Libre de Bruxelles, Brussels, Belgium.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2022 Jul; Vol. 30 (5), pp. 1190-1198. Date of Electronic Publication: 2021 Jun 30.
DOI: 10.1080/09273948.2020.1869267
Abstrakt: Purpose: To describe subclinical chorioretinal lesions revealed by indocyanine green angiography (ICGA) and their evolution under systemic treatment in tubulointerstitial nephritis and uveitis (TINU) patients.
Methods: Retrospective case series of three patients with TINU syndrome. Choroidal and retinal involvement were assessed by fluorescein angiography (FA) and ICGA.
Results: Three patients were analyzed. FA demonstrated hot disc, associated in two cases with retinal vascular leakage, and ICGA revealed subclinical chorioretinal dots in all three cases. Given the presence of posterior uveitis and deterioration of kidney function, asystemic treatment by oral methylprednisolone was started. Persistence of retinal and choroidal inflammations under systemic corticosteroids required association with immunosuppressive agent to control the disease activity.
Conclusion: Multimodal imaging and more precisely ICGA is useful to assess subclinical choroidal inflammation and monitor treatment response in TINU syndrome. Immunosuppression needs to be revised and adapted when uveitis and/or kidney function are unresponsive to systemic steroids.
Abbreviations: TINU: tubulointerstitial nephritis and uveitis; TIN: tubulointerstitial nephritis; ACE: angiotensin-converting enzyme; RF: rheumatoid factor; Uβ2M: urinary β-2microglobulin; AMPPE: acute multifocal placoid pigment epitheliopathy; FA: fluorescein angiography; ICGA: indocyanine green angiography; CT: computed tomography.
Databáze: MEDLINE
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