Breast Milk and Breastfeeding of Infants Born to SARS-CoV-2 Positive Mothers: A Prospective Observational Cohort Study.

Autor:	Kunjumon B; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Wachtel EV; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Lumba R; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Quan M; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Remon J; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Louie M; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Verma S; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Moffat MA; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Kouba I; Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York., Bennett TA; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York.; Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York City, New York., Mejia CM; Department of Pediatrics, New York University Long Island School of Medicine, New York City, New York., Mally PV; Department of Pediatrics, New York University Grossman School of Medicine, New York City, New York., Lin X; Department of Pediatrics, New York University Long Island School of Medicine, New York City, New York., Hanna N; Department of Pediatrics, New York University Long Island School of Medicine, New York City, New York.
Jazyk:	angličtina
Zdroj:	American journal of perinatology [Am J Perinatol] 2021 Sep; Vol. 38 (11), pp. 1209-1216. Date of Electronic Publication: 2021 Jun 28.
DOI:	10.1055/s-0041-1731451
Abstrakt:	Objective: There are limited published data on the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus from mothers to newborns through breastfeeding or from breast milk. The World Health Organization released guidelines encouraging mothers with suspected or confirmed COVID-19 to breastfeed as the benefits of breastfeeding outweighs the possible risk of transmission. The objective of this study was to determine if SARS-CoV-2 was present in the breast milk of lactating mothers who had a positive SARS-CoV-2 nasopharyngeal swab test prior to delivery, and the clinical outcomes for their newborns. Study Design: This was a single-center, observational, prospective cohort study. Maternal-newborn dyads that delivered at New York University Langone Hospital Brooklyn with confirmed maternal SARS-CoV-2 positive screen test at the time of admission were recruited for the study. Breast milk samples were collected during postpartum hospitalization and tested for the presence of SARS-CoV-2 genes N1 and N2 by two-step reverse transcription polymerase chain reaction. Additionally, the clinical characteristics of the maternal newborn dyad, results of nasopharyngeal SARS-CoV-2 testing, and neonatal follow-up data were collected. Results: A total of 19 mothers were included in the study and their infants who were all fed breast milk. Breast milk samples from 18 mothers tested negative for SARS-CoV-2, and 1 was positive for SARS-CoV-2 RNA. The infant who ingested the breast milk that tested positive had a negative nasopharyngeal test for SARS-CoV-2, and had a benign clinical course. There was no evidence of significant clinical infection during the hospital stay or from outpatient neonatal follow-up data for all the infants included in this study. Conclusion: In a small cohort of SARS-CoV-2 positive lactating mothers giving birth at our institution, most of their breast milk samples (95%) contained no detectable virus, and there was no evidence of COVID-19 infection in their breast milk-fed neonates. Key Points: · Breast milk may rarely contain detectable SARS-CoV-2 RNA and was not detected in asymptomatic mothers.. · Breast milk with detectable SARS-CoV-2 RNA from a symptomatic mother had no clinical significance for her infant.. · Breast feeding with appropriate infection control instructions appears to be safe in mother with COVID infection.. Competing Interests: None declared. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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