Spike Activity in the Ventromedial Nucleus of Rat Hypothalamus during Aging.

Autor: Moiseev KY; Yaroslalv State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia., Spirichev AA; Yaroslalv State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia., Pankrasheva LG; Yaroslalv State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia., Martyusheva AS; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Abramova AY; P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia., Maslyukov PM; Yaroslalv State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia. mpm@ysmu.ru.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 May; Vol. 171 (2), pp. 251-253. Date of Electronic Publication: 2021 Jun 26.
DOI: 10.1007/s10517-021-05205-4
Abstrakt: Spike activity of neurons in the ventromedial nucleus (VMN) of the hypothalamus in adult (6-8 months) and aged (2 years) male rats was studied by the in vivo extracellular method using stereotaxic insertion of microelectrodes. In all animals, firing frequency of most VMN neurons increased in response to glucose administration. However, in aged rats, the mean baseline and glucose-induced spike frequencies of VMN neurons were lower than in adult animals. These results support the hypothesis that aging is associated with a decrease in the functional activity of hypothalamic neurons.
Databáze: MEDLINE
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