Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers.

Autor: Bordoni L; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Camerino, Italy., Petracci I; School of Advanced Studies, University of Camerino, Camerino, Italy., Pelikant-Malecka I; Division of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.; Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland., Radulska A; Division of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.; Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland., Piangerelli M; Computer Science Division and Mathematics Division, School of Science and Technology, University of Camerino, Camerino, Italy., Samulak JJ; Doctoral School, Gdansk University of Physical Education and Sport, Gdansk, Poland., Lewicki L; Department of Cardiology and Angiology, Kashubian Center for Heart and Vascular Diseases, Pomeranian Hospitals, Wejherowo, Poland., Kalinowski L; Division of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.; Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland.; Department of Mechanics of Materials and Structures, Gdansk University of Technology, Gdansk, Poland., Gabbianelli R; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Camerino, Italy., Olek RA; Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland.
Jazyk: angličtina
Zdroj: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Jul; Vol. 35 (7), pp. e21694.
DOI: 10.1096/fj.202100056R
Abstrakt: Among cardiovascular disease (CVD) biomarkers, the mitochondrial DNA copy number (mtDNAcn) is a promising candidate. A growing attention has been also dedicated to trimethylamine-N-oxide (TMAO), an oxidative derivative of the gut metabolite trimethylamine (TMA). With the aim to identify biomarkers predictive of CVD, we investigated TMA, TMAO, and mtDNAcn in a population of 389 coronary artery disease (CAD) patients and 151 healthy controls, in association with established risk factors for CVD (sex, age, hypertension, smoking, diabetes, glomerular filtration rate [GFR]) and troponin, an established marker of CAD. MtDNAcn was significantly lower in CAD patients; it correlates with GFR and TMA, but not with TMAO. A biomarker including mtDNAcn, sex, and hypertension (but neither TMA nor TMAO) emerged as a good predictor of CAD. Our findings support the mtDNAcn as a promising plastic biomarker, useful to monitor the exposure to risk factors and the efficacy of preventive interventions for a personalized CAD risk reduction.
(© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)
Databáze: MEDLINE
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