Hemorheological responses to an acute bout of maximal exercise in Veterans with Gulf War Illness.

Autor: Qian W; Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA; New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA., Klein-Adams JC; Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA., Ndirangu DS; Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA., Chen Y; Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA; New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA., Falvo MJ; Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA; New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA. Electronic address: Michael.Falvo@va.gov., Condon MR; New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA; Surgical Services, Veterans Affairs New Jersey Health Care System, East Orange, NJ, USA.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Sep 01; Vol. 280, pp. 119714. Date of Electronic Publication: 2021 Jun 16.
DOI: 10.1016/j.lfs.2021.119714
Abstrakt: Background: Altered red blood cell (RBC) deformability has been reported in Veterans with Gulf War Illness (GWI) who endorse exercise-induced symptom exacerbation and fatigue. However, it is unknown whether altered RBC deformability is worsened secondary to exercise.
Objective: To evaluate RBC deformability in response to maximal exercise in individuals with and without GWI.
Methods: Seventeen Veterans with GWI and 11 controls performed maximal exercise and provided blood samples (pre-, immediately post- and 60-min post-exercise). We calculated RBC deformation at infinite stress (EI MAX ), shear stress for half-deformation (SS 1/2 ) and their ratio (SS 1/2 /EI MAX ) via repeated measures ANOVA with group and time as factors.
Results: A moderate interaction effect (p = 0.08, η 2 p  = 0.10), large main effect for group (p = 0.02, η 2 p  = 0.19) and moderate main effect for time (p = 0.20, η 2 p  = 0.06) were observed for EI MAX , but only the main effect for group reached statistical significance. Changes in SS 1/2 and SS 1/2 /EI MAX over time were similar between cases and controls as were main effects.
Conclusions: Veterans with GWI had more deformable RBCs in comparison to controls that was unaffected by maximal exercise. Future studies to confirm our findings and identify associated mechanisms are warranted.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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