Fine-tuning multiciliated cell differentiation at the post-transcriptional level: contribution of miR-34/449 family members.

Autor: Loukas I; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Skamnelou M; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Tsaridou S; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Bournaka S; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Grigoriadis S; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Taraviras S; Laboratory of Physiology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Lygerou Z; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece., Arbi M; Laboratory of Biology, School of Medicine, University of Patras, Rio, Patras, 26504, Greece.
Jazyk: angličtina
Zdroj: Biological reviews of the Cambridge Philosophical Society [Biol Rev Camb Philos Soc] 2021 Oct; Vol. 96 (5), pp. 2321-2332. Date of Electronic Publication: 2021 Jun 15.
DOI: 10.1111/brv.12755
Abstrakt: Cell differentiation is a process that must be precisely regulated for the maintenance of tissue homeostasis. Differentiation towards a multiciliated cell fate is characterized by well-defined stages, where a transcriptional cascade is activated leading to the formation of multiple centrioles and cilia. Centrioles migrate and dock to the apical cell surface and, acting as basal bodies, give rise to multiple motile cilia. The concerted movement of cilia ensures directional fluid flow across epithelia and defects either in their number or structure can lead to disease phenotypes. Micro-RNAs (miRNAs; miRs) are small, non-coding RNA molecules that play an important role in post-transcriptional regulation of gene expression. miR-34b/c and miR-449a/b/c specifically function throughout the differentiation of multiciliated cells, fine-tuning the expression of many different centriole- and cilia-related genes. They strictly regulate the expression levels of genes that are required both for commitment towards the multiciliated cell fate (e.g. Notch) and for the establishment and maintenance of this fate by regulating the expression of transcription factors and structural components of the pathway. Herein we review miR-34 and miR-449 spatiotemporal regulation along with their roles during the different stages of multiciliogenesis.
(© 2021 Cambridge Philosophical Society.)
Databáze: MEDLINE
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