Extraocular Sebaceous Carcinoma Treated With Mohs Micrographic Surgery-A 24-Year Retrospective Review of Tumor Characteristics and Treatment Outcomes.
| Autor: | Seago M; Division of Dermatology and Mohs Surgery, Scripps Clinic, La Jolla, California.; Department of Dermatology, Naval Medical Center San Diego, San Diego, California., Hosking AM; Department of Medicine, Scripps Mercy Hospital, San Diego, California., Greenway HT; Division of Dermatology and Mohs Surgery, Scripps Clinic, La Jolla, California., Kelley B; Division of Dermatology and Mohs Surgery, Scripps Clinic, La Jolla, California. |
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| Jazyk: | angličtina |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2021 Sep 01; Vol. 47 (9), pp. 1195-1199. |
| DOI: | 10.1097/DSS.0000000000003105 |
| Abstrakt: | Background: Extraocular sebaceous carcinoma (SC) is rare, with distinct features from its ocular counterpart. These neoplasms have been associated with Muir-Torre syndrome (MTS). Associated internal malignancies include gastrointestinal and genitourinary. Objective: Assess for local recurrence, metastasis, disease-specific death, and additional malignancies in patients with extraocular SC treated with Mohs micrographic surgery (MMS) at a single referral center. Methods: Review of patients with extraocular SC treated with MMS between 1995 and 2019. Follow-up was obtained by chart review. Results: Thirty-eight patients with 41 tumors were identified (25, 66% male). During a mean follow-up of 5.9 ± 5 years, one case of metastasis was identified in an incompletely treated case. No recurrence was identified in the remaining 40 tumors. Five of 41 (12%) tumors had aggressive histologic features. Seven of 38 (18%) patients had a diagnosis of MTS or associated risk factors. There was no association between MTS or its risk factors and high-risk tumors. Conclusion: There were no incidences of local recurrence, metastasis, or disease-specific death in cases treated completely with MMS. Metastasis and disease-specific death occurred in an incompletely treated case, highlighting the risk associated with aggressive tumors. (Copyright © 2021 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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