Evaluation of pentoxifylline and ferrous sulfate for treatment of lower limb venous ulcers.
| Autor: | Lemos PC; Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil., Lins EM; Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil., Pinto FCM; Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil., Aguiar JLA; Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil., Appolonio F; Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil., Breno F; Universidade Federal de Pernambuco - UFPE, Recife, PE, Brasil. |
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| Jazyk: | angličtina |
| Zdroj: | Jornal vascular brasileiro [J Vasc Bras] 2021 May 24; Vol. 20, pp. e2020167. Date of Electronic Publication: 2021 May 24. |
| DOI: | 10.1590/1677-5449.200167 |
| Abstrakt: | Background: Venous ulcers (VU) are the most advanced stage of chronic venous disease (CVD) of the lower limbs. They are frequently associated with episodes of hemorrhage that can provoke chronic anemia (CA), delaying healing. There are no studies in the literature analyzing the prevalence of CA among patients with VU of the lower limbs and few studies have analyzed use of pentoxifylline to treat VU of the lower limbs. Objectives: To evaluate the prevalence of CA in patients with lower limb VU and responses to treatment with ferrous sulfate (SF) compared with a combination of SF plus pentoxifylline as adjuvant treatment for VU of the lower limbs. Methods: A total of 67 patients with lower limb VU were recruited from a Lymphedema and Angiodysplasia Clinic at the Hospital das Clínicas, Recife, PE, Brazil. After initial clinical and laboratory assessments, patients diagnosed with CA were randomized into one of two groups: a control group, given SF (900 mg/day oral route), or a study group, treated with SF (900 mg/day oral route) and pentoxifylline (1,200 mg/day). All were reassessed after 90 days. Results: Twenty-seven patients (40%) had CA. After treatment, increases were observed in hemoglobin and hematocrit levels, iron kinetics had improved, and both depth and area of VU had reduced in both groups, without statistically significant differences. Conclusions: A high prevalence of anemia was detected in the study population. The combination of SF and pentoxifylline was not more effective than SF alone for adjuvant treatment of VU of the lower limbs. Competing Interests: Conflicts of interest:No conflicts of interest declared concerning the publication of this article. (Copyright: © 2021 The Authors.) |
| Databáze: | MEDLINE |
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