Comparison Between Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for Incidence of Lung Cancer: A Retrospective Study.

Autor:	Kumar P; Medicine, Jinnah Sindh Medical University, Karachi, PAK., Kumar V; Internal Medicine, Cleveland Clinic Abu Dhabi, Abu Dhabi, ARE., Murlidhar F; Internal Medicine, Chandka Medical College Hospital, Larkana, PAK., Fatima A; Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK., Jahangir M; Anesthesiology, Civil Hospital Karachi, Karachi, PAK., Khalid D; Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK., Memon MK; Internal Medicine, Liaquat University of Medical and Health Sciences, Hyderabad, PAK., Memon S; Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK., Kumar B; Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 May 01; Vol. 13 (5), pp. e14788. Date of Electronic Publication: 2021 May 01.
DOI:	10.7759/cureus.14788
Abstrakt:	Introduction: Angiotensin-converting enzyme inhibitor (ACEI) and angiotensin II receptor blockers (ARBs) are taken as the first treatment option for hypertensive patients. The various global trials have suggested that ACEIs and ARBs may increase risk of lung cancer; however, the results are contradictory and there is no local study available. This study is conducted to compare the incidence of lung cancers in patients on ACEIs and ARBs. Methods: This retrospective study, conducted in a major cardiology unit of a tertiary care hospital in Pakistan, included patients diagnosed with hypertension, between 2005 and 2010, who were prescribed either ACEIs or ARBs. During the period of 2005 to 2010, 47,823 naïve hypertensive patients were reported in the outpatient department of the cardiology unit. Of which, 22,241 were prescribed ACEI and 25,582 were prescribed ARBs. After sorting patient data based on our inclusion criteria, n = 14,891 participants were included in the ACEI group and n = 19,112 participants were included in the ARB group. Results: The incidence of lung cancer in the ACEI and ARB group was n = 165 and n = 160, respectively. In this study, the overall incidence rates of lung cancer in the ACEI and ARB cohorts were 12.2 and 16.6 per 10,000 person-years, respectively. The hazard ratio was 1.32 (95% confidence interval: 1.06-1.64; p-value: 0.01). Conclusion: In this study, the incidence of lung cancer was relatively more among people using ACEIs than ARBs. Hence, patients undergoing long-term treatment with ACEIs need regular follow-up and proper scanning to avoid grave complications. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Kumar et al.)
Databáze:	MEDLINE
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