The Longitudinal Effects of Blood Pressure and Hypertension on Neurocognitive Performance in People Living With HIV.

Autor:	Guzman VA; Department of Neurology, Columbia University Irving Medical Center, New York, NY.; Department of Neurology, the Icahn School of Medicine at Mount Sinai, New York, NY.; Department of Psychology, Fordham University, New York, NY., Cham H; Department of Psychology, Fordham University, New York, NY., Gutierrez J; Department of Neurology, Columbia University Irving Medical Center, New York, NY., Byrd D; Department of Neurology, the Icahn School of Medicine at Mount Sinai, New York, NY.; Department of Psychology, Queens College and the Graduate Center, CUNY, Queens, New York., Morris EP; Department of Psychology, Fordham University, New York, NY.; Department of Psychology, University of Michigan, Ann Arbor, MI., Tureson K; Department of Psychology, Fordham University, New York, NY.; Department of Psychology, University of Southern California, Los Angeles, CA; and., Morgello S; Department of Neurology, the Icahn School of Medicine at Mount Sinai, New York, NY.; Departments of Pathology and Neuroscience, the Icahn School of Medicine at Mount Sinai, New York, NY., Mindt MR; Department of Neurology, the Icahn School of Medicine at Mount Sinai, New York, NY.; Department of Psychology, Fordham University, New York, NY.
Jazyk:	angličtina
Zdroj:	Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2021 Oct 01; Vol. 88 (2), pp. 197-205.
DOI:	10.1097/QAI.0000000000002740
Abstrakt:	Background: Hypertension (HTN) and HIV are salient risk factors for cerebral small vessel disease and neurocognitive (NC) impairment, yet the effects of HTN on NC performance in persons living with HIV remain poorly understood. This is the first study to examine the longitudinal associations between blood pressure (BP), HTN, and pulse pressure (PP) with NC performance in persons living with HIV. Setting: New York City. Methods: Analysis of medical, NC, and virologic data from 485 HIV+ participants was collected by the Manhattan HIV Brain Bank, a prospective, observational, longitudinal study of neuroHIV. A series of multilevel linear growth curve models with random intercepts and slopes were estimated for BP, HTN status, and PP to predict the change in NC performance. Results: The baseline prevalence of HTN was 23%. Longitudinal changes in diastolic and systolic pressure were associated with a 10.5-second and 4-second increase in the Grooved Pegboard Test nondominant hand performance, respectively. A longitudinal change in diastolic BP was also associated with a 0.3-point decline in correct categories and 3-point increase in perseverative responses and total errors on the Wisconsin Card Sorting Test. Increasing odds of prevalent and/or incident HTN were associated with a 0.1-point decrease in correct categories and a 0.8-point increase in total errors on the Wisconsin Card Sorting Test. There was no association between PP and NC performance. Conclusions: The results indicate linear longitudinal relations for BP and HTN with poorer NC test performance, particularly in psychomotor and executive functions in persons with HIV. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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