Nanodiamond-chitosan functionalized hernia mesh for biocompatibility and antimicrobial activity.

Autor: Saha T; School of Engineering, RMIT University, Melbourne, Australia.; Dhaka University of Engineering and Technology, Gazipur, Gazipur, Bangladesh., Houshyar S; School of Engineering, RMIT University, Melbourne, Australia., Sarker SR; Center for Advanced Materials and Industrial Chemistry (CAMIC), School of Science, RMIT University, Melbourne, Australia.; Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Dhaka, Bangladesh., Pyreddy S; Ian Potter NanoBiosensing Facility, NanoBiotechnology Research Laboratory (NBRL), School of Science, RMIT University, Melbourne, Australia., Dekiwadia C; RMIT Microscopy and Microanalysis Facility, RMIT University, Melbourne, Australia., Nasa Z; Micro Nano Research Facility (MNRF), RMIT University, Melbourne, Australia., Padhye R; Center for Materials Innovation and Future Fashion (CMIFF), School of Fashion and Textiles, RMIT University, Australia., Wang X; Center for Materials Innovation and Future Fashion (CMIFF), School of Fashion and Textiles, RMIT University, Australia.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2021 Dec; Vol. 109 (12), pp. 2449-2461. Date of Electronic Publication: 2021 Jun 03.
DOI: 10.1002/jbm.a.37237
Abstrakt: Polypropylene (PP) mesh is most commonly used for the treatment of hernia and pelvic floor construction. However, some of the patients have a few complications after surgery due to the rejection or infection of the implanted meshes. The poor biocompatibility of PP mesh, low wettability results in poor cell attachment/proliferation and restricts the loading of antibacterial agent, leading to a slow healing process and high risk of infection after surgery. Here in this study, a new technique has been employed to develop a novel antimicrobial and biocompatible PP mesh modified with bioactive chitosan and functionalized nanodiamond (FND) for infection inhibition and acceleration of the healing process. An oxygen plasma treatment PP mesh was used then chitosan was strongly attached to the surface of the PP fibers. Subsequently, FND as an antibacterial agent was loaded into the chitosan modified PP fiber to provide desired antibacterial functions. The meshes were characterised with XRD, FTIR, SEM, EDX, water contact angle, confocal, and optical microscopy. The modified PP mesh with chitosan and FND showed a significant increase in its hydrophilicity and L929 fibroblast cell attachment. Furthermore, the modified mesh exhibited great antibacterial efficiency against Escherichia coli. Therefore, the newly developed technique to modify PP mesh could be a promising technique to generate a biocompatible PP mesh to accelerate the healing process and reduce the risk of infection after surgery.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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