| Autor: |
Aslam Khan MU; BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia.; Department of Polymer Engineering and Technology, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan.; Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.; Department of Metallurgy and Materials Engineering, CEET, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan., Al-Arjan WS; Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Binkadem MS; Department of Chemistry, Faculty of Science, University of Jeddah, Jeddah 21589, Saudi Arabia., Mehboob H; Department of Engineering Management, College of Engineering, Prince Sultan University, Rafha Street, Riyadh 11586, Saudi Arabia., Haider A; Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Punjab 46000, Pakistan., Raza MA; Department of Metallurgy and Materials Engineering, CEET, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan., Abd Razak SI; BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia.; Center for Advanced Composite Materials, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia., Hasan A; Biomedical Research Center, Qatar University, Doha 2713, Qatar.; Department of Mechanical and Industrial Engineering, Qatar University, Doha 2713, Qatar., Amin R; Department of Biology, College of Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia. |
| Abstrakt: |
Bone tissue engineering is an advanced field for treatment of fractured bones to restore/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible characteristics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO 2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO 2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young's modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 μm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast ( MC3T3-E1 ) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering. |
