Evaluation of Clinical Factors Predictive of Diabetes Remission Following Bariatric Surgery.

Autor: Mateo-Gavira I; Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain., Sánchez-Toscano E; Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain., Mayo-Ossorio MÁ; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain.; General Surgery Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain., Pacheco-García JM; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain.; General Surgery Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain., Prada-Oliveira JA; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain.; School of Medicine, Cadiz University (UCA), 11003 Cádiz, Spain., Vílchez-López FJ; Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 May 01; Vol. 10 (9). Date of Electronic Publication: 2021 May 01.
DOI: 10.3390/jcm10091945
Abstrakt: Bariatric surgery is an effective treatment for achieving significant weight loss and improving metabolic comorbidities such as type 2 diabetes mellitus (T2DM). The aim of our study was to investigate clinical factors related to T2DM remission in obese patients who had undergone bariatric surgery.
Methods: A cohort of patients with T2DM and a minimum of class II obesity undergoing bariatric surgery had their clinical and anthropometric variables assessed. The statistical evaluation included multivariate analyses of clinical factors predicting a T2DM remission two years post-surgery.
Results: 83 patients were included (mean age 44.13 ± 10.38 years). Two years post-surgery, the percentage of excess weight lost was 63.43 ± 18.59%, and T2DM was resolved in 79.5% of the patients. T2DM remission was directly related to a high body mass index (BMI) (OR: 1.886; p = 0.022) and the absence of macro-vascular complications (OR: 34.667; p = 0.002), while it was inversely associated with T2DM with a duration longer than 5 years (OR: 0.022; p = 0.040) and baseline insulin treatment (OR: 0.001; p = 0.009). 15.6% of the patients presented early complications and 20.5% developed late complications.
Conclusion: In our study sample, bariatric surgery proved to be an effective and safe technique for sustained medium-term weight loss and the resolution of T2DM. A higher baseline BMI, a shorter T2DM duration, non-insulin treatment, and the absence of macro-vascular complications are factors predictive of T2DM remission.
Databáze: MEDLINE
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