Wnt signaling pathway activities may be altered in primary Sjogren’s syndrome

Autor: Karataş A; Department of Rheumatology, Faculty of Medicine, Fırat University, Elazığ, Turkey, Ömercikoğlu Z; Department of Internal Medicine, Aybasti Hospital, Ordu, Turkey, Öz B; Department of Rheumatology, Faculty of Medicine, Fırat University, Elazığ, Turkey, Dağlı AF; Department of Pathology, Faculty of Medicine, Fırat University, Elazığ, Turkey, Çatak O; Department of Ophthalmology, Faculty of Medicine, Fırat University, Elazığ, Turkey, Erman F; Department of Medical Biochemistry, School of Medicine, Fırat University, Elazığ, Turkey, Şahin K; Department of Animal Nutrition, Faculty of Veterinary Science, Fırat University, Elazığ, Turkey, Gözel N; Department of Internal Medicine, Faculty of Medicine, Fırat University, Elazığ, Turkey, Koca SS; Department of Rheumatology, Faculty of Medicine, Fırat University, Elazığ, Turkey
Jazyk: angličtina
Zdroj: Turkish journal of medical sciences [Turk J Med Sci] 2021 Aug 30; Vol. 51 (4), pp. 2015-2022. Date of Electronic Publication: 2021 Aug 30.
DOI: 10.3906/sag-2102-367
Abstrakt: Background/aim: Sjögren’s syndrome (SS) is an autoimmune disease and its pathogenesis is still not completely clear. The wingless (Wnt)/β-catenin pathway has recently been shown to play an important role in inflammation. This study aims to determine the serum and saliva levels of Dickkopf (DKK)1 and sclerostin and to evaluate Wnt-1 and Wnt-3a expression in the salivary gland in patients with primary SS.
Materials and Methods: This study included 30 patients diagnosed with SS, 30 patients diagnosed with systemic lupus erythematosus (SLE), and 29 healthy controls. Serum and saliva levels of DKK1 and sclerostin were measured and the expressions of Wnt1 and Wnt3a in the salivary gland were measured immunohistochemically.
Results: Serum DKK1 and sclerostin levels were lower in the SS and SLE groups compared to the control group (both p < 0.001). Saliva DKK1 levels were higher in the SS group compared to the control and SLE groups (p = 0.004 and p = 0.009, respectively). Wnt1 and Wnt3a expression were found in salivary gland tissue samples in 71.4% of primary SS patients and relatively frequent than control group.
Conclusions: Serum DKK1 and sclerostin levels in primary SS and SLE were decreased. Moreover, levels of Wnt1 and Wnt3a expression in the salivary gland were also elevated in primary SS. Therefore, it can be concluded that the Wnt/β-catenin pathway activities may be altered in case of glandular inflammation.
(This work is licensed under a Creative Commons Attribution 4.0 International License.)
Databáze: MEDLINE
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