HMGB1-RAGE-moesin axis may be indicted for acne vulgaris.

Autor: Salem RM; Department of Dermatology and Andrology, Faculty of Medicine- Benha University, Benha, Egypt., El-Fallah AA; Department of Chemical and Clinical Pathology, Faculty of Medicine- Benha University, Benha, Egypt., Shaker R; Department of Public Health, Faculty of Medicine- Benha University, Benha, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2022 Apr; Vol. 21 (4), pp. 1642-1646. Date of Electronic Publication: 2021 Jun 15.
DOI: 10.1111/jocd.14261
Abstrakt: Background: High-mobility group box 1 (HMGB1)-receptor for advanced glycation end (RAGE)-moesin axis could be implicated in induction of inflammation. However, there is a scarcity in literature discussing the role of this axis in inflammatory skin disorders.
Aims: The aim of the present study was to evaluate the serum levels of HMGB1 and moesin in patients with inflammatory acne vulgaris.
Patients/methods: This comparative cross-sectional study included 66 inflammatory acne vulgaris patients classified according to Global Acne Grading System (GAGS) into three groups (22 patients each): mild, moderate, and severe acne vulgaris. In addition, 82 acne-free individuals were included as a control group. Serum HMGB 1 and moesin levels were measured using enzyme-linked immunosorbent assay kits.
Results: High-mobility group box 1 and moe sin serum levels in acne patients were significantly higher than the levels in control subjects (p = 0.04, 0.0005 respectively). Serum levels of both markers in severe acne patients and in those with post-acne scarring were elevated when compared to the levels in the other groups, and however, this elevation was significant only for moesin levels. There was a significant positive correlation between the serum levels of HMGB1 and moesin in the studied patient's sample (r = 0.3079, p = 0.011).
Conclusion: High-mobility group box 1-receptor for advanced glycation end-moesin axis may be implicated in acne vulgaris pathogenesis, and it may be a promising therapeutic target.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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