Intraoperative visualization of nerves using a myelin protein-zero specific fluorescent tracer.
Autor: | Buckle T; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. t.buckle@lumc.nl., Hensbergen AW; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands., van Willigen DM; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands., Bosse F; Neurologische Klinik, Heinrich-Heine University Dusseldorf, Düsseldorf, Germany., Bauwens K; ORSI Academy, Melle, Belgium., Pelger RCM; Department of Urology, Leiden University Medical Center, Leiden, The Netherlands., van Leeuwen FWB; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. f.w.b.van_leeuwen@lumc.nl.; ORSI Academy, Melle, Belgium. f.w.b.van_leeuwen@lumc.nl. |
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Jazyk: | angličtina |
Zdroj: | EJNMMI research [EJNMMI Res] 2021 May 29; Vol. 11 (1), pp. 50. Date of Electronic Publication: 2021 May 29. |
DOI: | 10.1186/s13550-021-00792-9 |
Abstrakt: | Background: Surgically induced nerve damage is a common but debilitating side effect in oncological surgery. With the aim to use fluorescence guidance to enable nerve-sparing interventions in future surgery, a fluorescent tracer was developed that specifically targets myelin protein zero (P0). Results: Truncated homotypic P0 protein-based peptide sequences were C-terminally functionalized with the far-red cyanine dye Cy5. The lead compound Cy5-P0 Conclusion: P0 |
Databáze: | MEDLINE |
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