Introgression of ASIP and TYRP1 Alleles Explains Coat Color Variation in Valais Goats.

Autor:	Henkel J; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3001 Bern, Switzerland.; DermFocus, University of Bern, 3001 Bern, Switzerland., Dubacher A; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3001 Bern, Switzerland., Bangerter E; Swiss Goat Breeding Association, 3052 Zollikofen, Switzerland., Herren U; Swiss Goat Breeding Association, 3052 Zollikofen, Switzerland., Ammann P; ProSpecieRara, 4052 Basel, Switzerland., Drögemüller C; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3001 Bern, Switzerland.; DermFocus, University of Bern, 3001 Bern, Switzerland., Flury C; School of Agricultural, Forest and Food Sciences, Bern University of Applied Sciences, 3052 Zollikofen, Switzerland., Leeb T; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3001 Bern, Switzerland.; DermFocus, University of Bern, 3001 Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	The Journal of heredity [J Hered] 2021 Aug 25; Vol. 112 (5), pp. 452-457.
DOI:	10.1093/jhered/esab024
Abstrakt:	The Valais Blackneck goat is a Swiss goat breed with a characteristic coat color phenotype. Before the revision of the breed standard in 1938, 4 different color varieties of Valais goats were known. Besides Blackneck animals resembling the modern breed standard, the brown and white Copperneck goat, the white Capra Sempione, and the greyish Grüenochte comprised the historic Valais goats. The brown pigmentation of Copperneck goats had previously been traced back to an introgression of a mutant TYRP1 allele from Toggenburg goats. In the present study, we identified additional introgression events of distinct ASIP alleles causing the remaining 2 rare coat color patterns within the Valais Blackneck goat breed. We identified the introgression of the AWt allele from Appenzell or Saanen goats in white Capra Sempione goats. Similarly, introgression of the Apc allele from Peacock goats resulted in the greyish Grüenochte phenotype. These results demonstrate past hybridization events between breeds that are separated today. A perfect genotype-phenotype association in 393 Valais goats supported the causality of the genotyped variants for the different coat color phenotypes. Our study gives insights into the introgression of functionally relevant copy number variant (CNV) alleles controlling pigmentation between goat breeds with strikingly different coat color patterns. (© The American Genetic Association. 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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