In Vivo Characterization of the Swine Airway Morphometry and Motion Based on Computed Tomographic Imaging During Respiration.

Autor:	Castro MGB; Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Drive, Room 3N320B, MSC 1182, Bethesda, MD 20892., Varble NA; Philips Research North America, Cambridge, MA 02141; Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Drive, Room 3N320, Bethesda, MD 20892., Yung RC; School of Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD 21205., Wood BJ; Clinical Center Radiology and Imaging Sciences, Center for Interventional Oncology, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892., Karanian JW; Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Drive, Room 3N320B, MSC 1182, Bethesda, MD 20892., Pritchard WF; Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Room 3N320B, MSC 1182, Bethesda, MD 20892.
Jazyk:	angličtina
Zdroj:	Journal of biomechanical engineering [J Biomech Eng] 2020 Dec 01; Vol. 142 (12).
DOI:	10.1115/1.4047550
Abstrakt:	Swine are a commonly used model in translational pulmonary research. However, in vivo airway morphometry during respiration has not been studied in extensive detail using modern imaging tools. Chest computed tomographic was performed in swine (n = 3) at multiple stages of respiration. Morphometric parameters of each airway segment at end-expiration and end-inspiration were compared as well as among matched anatomical regions (proximal and distal; ventral, lateral, and dorsal). Analysis included segment diameter, length, ellipticity, and the bifurcation angle between daughter branches. Deformation of the airway during respiration was qualitatively visualized using a point-to-point deformation map. Comparison of airway generation showed airway diameter and length were larger at end-inspiration in the fourth and seventh generations compared to end-expiration. Bifurcation angle was larger at end-inspiration compared to end-expiration. Analysis by anatomical region showed that length and bifurcation angle were larger at inspiration in the distal airway regions only. Regardless of respiratory phase, the lateral regions had larger diameters and lengths compared to the ventral and dorsal regions at similar generations and proximal regions had larger bifurcation angles. The findings that morphological changes were more prevalent in distal airways during respiration was confirmed by analysis of a deformation map. Compared to human airway models, the relative diameter may be smaller and length may be greater in swine in similar airway generations. This morphometric description of the swine airways during respiration may guide conduct of preclinical translational studies, revealing advantages and limitations of swine models for specific evaluations. Such morphometric parameters may directly determine the suitability of the swine model for the study of lung interventions, in terms of recapitulation of human morphometry dynamics. (Copyright © 2020 by ASME.)
Databáze:	MEDLINE
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